Results 1 to 10 of about 168,287 (208)

Structural Integrity of the -Carboxyglutamic Acid Domain of Human Blood Coagulation Factor IXa Is Required for Its Binding to Cofactor VIIIa [PDF]

, 1996
This report describes the analysis of a novel mutant human factor IX protein from a patient with hemophilia B (factor IX activity adenine transition) in exon 2 at nucleotide 6409 which results in a glycine --> arginine substitution at amino acid 12 in ...
High, Katherine A., Kasper, Carol K., Larson, Peter J., Monroe, Dougald M., Smith, Kenneth J., Stanfield-Oakley, Sherry A., VanDusen, William J.   +6 more
core   +3 more sources

Reliability of Brain Activity During a Supine Bilateral Leg Press and Association With Concurrent 3D Knee Joint Biomechanics. [PDF]

Eur J Neurosci
The current study established the leg press task as a reliable paradigm for investigating brain activity and concurrent knee joint kinematics. Furthermore, it identified a relationship between knee sagittal range of motion and brain activity in the right LOC and bilateral putamen, potentially reflecting enhanced sensorimotor integration and motor ...
Kim H, Zuleger TM, Slutsky-Ganesh AB, Anand M, Warren SM, Diekfuss JA, Schlink BR, Rush JL, Simon JE, Myer GD, Grooms DR.   +10 more
europepmc   +2 more sources

Membrane Interaction of the Factor VIIIa Discoidin Domains in Atomistic Detail. [PDF]

Biochemistry, 2015
Madsen JJ, Ohkubo YZ, Peters GH, Faber JH, Tajkhorshid E, Olsen OH.   +5 more
europepmc   +3 more sources

Cofactor activity in factor VIIIa of the blood clotting pathway is stabilized by an interdomain bond between His281 and Ser524 formed in factor VIII. [PDF]

J Biol Chem, 2014
Wakabayashi H, Monaghan M, Fay PJ.
europepmc   +2 more sources

Sequences flanking Arg336 in factor VIIIa modulate factor Xa-catalyzed cleavage rates at this site and cofactor function. [PDF]

J Biol Chem, 2012
DeAngelis JP, Wakabayashi H, Fay PJ.
europepmc   +3 more sources

Identification of residues in the 558-loop of factor VIIIa A2 subunit that interact with factor IXa. [PDF]

J Biol Chem, 2009
Jagannathan I, Ichikawa HT, Kruger T, Fay PJ.   +3 more
europepmc   +3 more sources

Hyperactivity of factor IX Padua (R338L) depends on factor VIIIa cofactor activity. [PDF]

JCI Insight, 2019
Samelson-Jones BJ, Finn JD, George LA, Camire RM, Arruda VR.   +4 more
europepmc   +3 more sources

Variable contributions of basic residues forming an APC exosite in the binding and inactivation of factor VIIIa. [PDF]

Biochemistry, 2013
Takeyama M, Wintermute JM, Manithody C, Rezaie AR, Fay PJ.   +4 more
europepmc   +3 more sources

Structural insights into the interaction of blood coagulation co-factor VIIIa with factor IXa: a computational protein-protein docking and molecular dynamics refinement study. [PDF]

Biochem Biophys Res Commun, 2014
Venkateswarlu D.
europepmc   +3 more sources

Combining mutations that modulate inter-subunit interactions and proteolytic inactivation enhance the stability of factor VIIIa. [PDF]

Thromb Haemost, 2014
Wakabayashi H, Wintermute JM, Fay PJ.
europepmc   +3 more sources