Results 21 to 30 of about 12,705,637 (166)

FRONTIER1: a partially randomized phase 2 study assessing the safety, pharmacokinetics, and pharmacodynamics of Mim8, a factor VIIIa mimetic

Journal of Thrombosis and Haemostasis, 2023
Steven R. Lentz, Pratima Chowdary, Lidia Gil, Francisco José López‐Jaime, Johnny Mahlangu, Irina Matytsina, Anne Louise Nielsen, Jerzy Windyga   +7 more
openalex   +2 more sources

Localization of Factor IXa and Factor VIIIa Interactive Sites (*) [PDF]

Journal of Biological Chemistry, 1995
The contribution of the catalytic and noncatalytic domains of factor IXa to the interaction with its cofactor, factor VIIIa, was evaluated. Two proteolytic fragments of factor IXa, lacking some or all of the serine protease domain, failed to mimic the ...
Lynn M. O'Brien, L. Medved, P. Fay
semanticscholar   +3 more sources

NXT007 enhances in vitro coagulation potential in the coexistence of emicizumab in hemophilia A through distinct complex formation [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: NXT007 is a factor (F)VIIIa-mimetic bispecific antibody (BsAb) for hemophilia A (HA), engineered from emicizumab. It is designed to achieve non-hemophiliac levels of plasma coagulation potential and is currently under clinical development. In
Kazuki Yamaguchi, Kenta Haraya, Hikaru Koga, Kei Nishimura, Keito Inaba, Masaru Muraoka, Atsushi Muto, Takehisa Kitazawa   +7 more
doaj   +2 more sources

Molecular orientation of factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer. [PDF]

Biochem J, 2013
Wakabayashi H, Fay PJ.
europepmc   +2 more sources

Structural insights into the interaction of blood coagulation co-factor VIIIa with factor IXa: a computational protein-protein docking and molecular dynamics refinement study. [PDF]

Biochem Biophys Res Commun, 2014
Venkateswarlu D.
europepmc   +2 more sources

Variable contributions of basic residues forming an APC exosite in the binding and inactivation of factor VIIIa. [PDF]

Biochemistry, 2013
Takeyama M, Wintermute JM, Manithody C, Rezaie AR, Fay PJ.   +4 more
europepmc   +2 more sources

The Gla Domain of Factor IXa Binds to Factor VIIIa in the Tenase Complex* [PDF]

Journal of Biological Chemistry, 2003
During blood coagulation factor IXa binds to factor VIIIa on phospholipid membranes to form an enzymatic complex, the tenase complex. To test whether there is a protein-protein contact site between the γ-carboxyglutamic acid (Gla) domain of factor IXa ...
M. Blostein, B. Furie, I. Rajotte, B. Furie   +3 more
semanticscholar   +4 more sources

Identification of residues in the 558-loop of factor VIIIa A2 subunit that interact with factor IXa. [PDF]

J Biol Chem, 2009
Jagannathan I, Ichikawa HT, Kruger T, Fay PJ.   +3 more
europepmc   +3 more sources

Factor IXa protects factor VIIIa from activated protein C. Factor IXa inhibits activated protein C-catalyzed cleavage of factor VIIIa at Arg562

Journal of Biological Chemistry, 1994
Factor VIIIa is inactivated by both factor IXa and activated protein C. The latter protease rapidly attacked a site at Arg562 (A2 subunit), whereas both proteases slowly cleaved factor VIIIa at Arg336 (A1 subunit). Cofactor inactivation catalyzed by activated protein C was 8-fold faster than that catalyzed by factor IXa. Simultaneous reaction of factor
Lisa M. Regan, Barry J. Lamphear, Christine F. Huggins, F. J. Walker, Philip J. Fay   +4 more
openalex   +3 more sources

Model for the Factor VIIIa-dependent Decay of the Intrinsic Factor Xase [PDF]

Journal of Biological Chemistry, 1996
Philip J. Fay, Tammy L. Beattie, Lisa M. Regan, Lynn O'Brien, Randal J. Kaufman   +4 more
openalex   +3 more sources