Results 31 to 40 of about 12,705,637 (166)

Factor VIIIa regulates substrate delivery to the intrinsic factor X‐activating complex [PDF]

The FEBS Journal, 2005
Activation of coagulation factor X (fX) by activated factors IX (fIXa) and VIII (fVIIIa) requires the assembly of the enzyme–cofactor–substrate fIXa–fVIIIa–fX complex on negatively charged phospholipid membranes. Using flow cytometry, we explored formation of the intermediate membrane‐bound binary complexes of fIXa, fVIIIa, and fX.
Mikhail A. Panteleev, Natalya M. Ananyeva, Nicholas J. Greco, Фазоил И. Атауллаханов, Evgueni L. Saenko   +4 more
openalex   +4 more sources

Interaction of Factor IXa with Factor VIIIa [PDF]

Journal of Biological Chemistry, 1997
Akash Mathur, Degang Zhong, Arun K. Sabharwal, Kenneth J. Smith, S Paul Bajaj   +4 more
openalex   +3 more sources

Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity.

Journal of Biological Chemistry, 1991
Philip J. Fay, T. Smudzin, F. J. Walker
openalex   +2 more sources

Sequences flanking Arg336 in factor VIIIa modulate factor Xa-catalyzed cleavage rates at this site and cofactor function. [PDF]

J Biol Chem, 2012
DeAngelis JP, Wakabayashi H, Fay PJ.
europepmc   +3 more sources

Role of crotoxin in coagulation: novel insights into anticoagulant mechanisms and impairment of inflammation-induced coagulation [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2020
Background: Snake venom phospholipases A2 (svPLA2) are biologically active toxins, capable of triggering and modulating a wide range of biological functions.
Bruna Terada Gimenez, Gabriel Neves Cezarette, Aline de Sousa Bomfim, Wuelton Marcelo Monteiro, Elisa Maria de Sousa Russo, Fabiani Gai Frantz, Suely Vilela Sampaio, Marco Aurelio Sartim   +7 more
doaj   +1 more source

Binding of factor VIIIa and factor VIII to factor IXa on phospholipid vesicles.

Journal of Biological Chemistry, 1992
The activation of factor X by factor IXa (fIXa) in the presence of phosphatidylcholine-phosphatidylserine (PCPS) vesicles is markedly accelerated by thrombin-activated factor VIII (fVIIIa). The interaction between highly purified fVIIIa and fIXa in this complex was studied fluorometrically at 25 degrees C by using a derivative of D-phenylalanyl-prolyl ...
Edward J. Duffy, Ernest T. Parker, Vasantha P. Mutucumarana, Arthur E. Johnson, Pete Lollar   +4 more
openalex   +3 more sources

Protein C Pathway in Paediatric and Neonatal Sepsis

Frontiers in Pediatrics, 2022
Protein C plays a major role in the physiological regulation of coagulation pathways through inactivation of factor Va, factor VIIIa, and plasminogen activator inhibitor.
Hassan Eliwan, Hassan Eliwan, Murwan Omer, Ellen McKenna, Lynne A. Kelly, Lynne A. Kelly, Lynne A. Kelly, Beatrice Nolan, Irene Regan, Irene Regan, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy   +15 more
doaj   +1 more source

Protease and EGF1 Domains of Factor IXa Play Distinct Roles in Binding to Factor VIIIa

Journal of Biological Chemistry, 1999
Akash Mathur, S Paul Bajaj
openalex   +2 more sources

Design of a Superior Factor VIIIa Mimetic By Coupling a Membrane Binding Domain to a Factor IXa Binding Antibody Fragment

Blood, 2023
Emicizumab is a bispecific antibody that augments Factor X (FX) activation by factor IXa (FIXa) in the absence of factor VIIIa (FVIIIa) by binding and approximating the substrate FX and protease FIXa.
Shekhar Kumar, S. Krishnaswamy
semanticscholar   +1 more source

Proteolytic interactions of factor IXa with human factor VIII and factor VIIIa. [PDF]

Blood, 1992
Abstract Factor IXa was shown to inactivate both factor VIII and factor VIIIa in a phospholipid-dependent reaction that could be blocked by an antifactor IX antibody. Factor IXa-catalyzed inactivation correlated with proteolytic cleavages within the A1 subunit of factor VIIIa and within the heavy chain (contiguous A1-A2-B domains) of ...
Barry, Lamphear, Philip, Fay
semanticscholar   +4 more sources