Results 51 to 60 of about 12,705,637 (166)

Asymptomatic type B right atrial thrombus in a case with protein S deficiency

Annals of Cardiac Anaesthesia, 2014
Thirty seven year old asymptomatic male underwent routine medical examination which revealed an abnormal mass in the right atrium. Family history was not suggestive of any cardiac or malignant disease.
Rajinder Singh Rawat, Yatin Mehta, Dheeraj Arora, Naresh Trehan   +3 more
doaj   +1 more source

Phylogenetic Analysis, Lineage-Specific Expansion and Functional Divergence of seed dormancy 4-Like Genes in Plants. [PDF]

PLoS ONE, 2016
The rice gene seed dormancy 4 (OsSdr4) functions in seed dormancy and is a major factor associated with pre-harvest sprouting (PHS). Although previous studies of this protein family were reported for rice and other species, knowledge of the evolution of ...
Saminathan Subburaj, Shuanghe Cao, Xianchun Xia, Zhonghu He   +3 more
doaj   +1 more source

Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit

Journal of Biological Chemistry, 1991
Heterodimeric human factor VIII was proteolytically activated by catalytic levels of thrombin to yield the (labile) active cofactor factor VIIIa possessing an initial specific activity of approximately 80 units/microgram. Activation paralleled the generation of fragments A1 and A2 derived from the heavy chain and A3-C1-C2 derived from the light chain ...
Philip J. Fay, P.J. Simpson Haidaris, T. Smudzin   +2 more
openalex   +3 more sources

Fibrin stimulates platelets to increase factor VIIIa binding site expression [PDF]

Journal of Thrombosis and Haemostasis, 2004
Factor (F)VIII functions as an enzymatic cofactor on the membranes of stimulated platelets. However, thrombin stimulates platelets to express only a small number of binding sites for FVIII. We wished to determine whether molecules that are likely to be present in a developing thrombus stimulate platelets to up-regulate FVIII binding site expression ...
J E, Phillips, S T, Lord, G E, Gilbert
openaire   +2 more sources

A mutated factor X activatable by thrombin corrects bleedings in vivo in a rabbit model of antibody-induced hemophilia A

Haematologica, 2019
Rendering coagulation factor X sensitive to thrombin was proposed as a strategy that can bypass the need for factor VIII. In this paper, this non-replacement strategy was evaluated in vitro and in vivo in its ability to correct factor VIII but also ...
Toufik Abache, Alexandre Fontayne, Dominique Grenier, Emilie Jacque, Alain Longue, Anne-Sophie Dezetter, Béatrice Souilliart, Guillaume Chevreux, Damien Bataille, Sami Chtourou, Jean-Luc Plantier   +10 more
doaj   +1 more source

Cerebellar and Brainstem White Matter Geometric Alterations in Multiple System Atrophy: A DFA-Based Biomarker for Disease Staging. [PDF]

CNS Neurosci Ther
Director field analysis (DFA) uncovers spatially divergent white matter degeneration in MSA‐C: cerebellar fiber simplification (decreased splay/bend) reflects Wallerian degeneration, while brainstem twist reduction (decreased twist) tracks disease progression (AUC = 0.95).
Zhu H, Zhu S, Zhao M, Zhu Z, Shao Y, Lu X, Liu T, Zhu H, Shu N, Lin H, Cheng J.   +10 more
europepmc   +2 more sources

Ile73Asn mutation in protein C introduces a new N-linked glycosylation site on the first EGF-domain of protein C and causes thrombosis

Haematologica, 2020
Activated protein C exerts its anticoagulant activity by protein S-dependent inactivation of factors Va and VIIIa by limited proteolysis. We identified a venous thrombosis patient who has plasma protein C antigen level of 63% and activity levels of 44 ...
Yeling Lu, Padmaja Mehta-D’souza, Indranil Biswas, Bruno O. Villoutreix, Xuefeng Wang, Qiulan Ding, Alireza R. Rezaie   +6 more
doaj   +1 more source

Exploring potential anticoagulant drug formulations using thrombin generation test

Biochemistry and Biophysics Reports, 2016
Many anticoagulant drugs inhibiting proteins of the coagulation cascade have been developed. The main targets of anticoagulant drugs are thrombin and factor Xa; inhibiting these factors delays thrombus growth, thus preventing thrombosis while increasing ...
Elena Zavyalova, Alexey Kopylov
doaj   +1 more source

An engineered interdomain disulfide bond stabilizes human blood coagulation factor VIIIa [PDF]

Journal of Thrombosis and Haemostasis, 2003
The blood coagulation disorder, hemophilia A, is caused by deficiency of coagulation factor (F)VIII. Hemophilia A is now treated by infusions of pure FVIII, but the activity of FVIII is limited because it is unstable following activation by thrombin. This instability of activated FVIII is the result of dissociation of the A2 subunit.
Gale, Andrew, Pellequer, Jean-Luc
openaire   +3 more sources

Characterization of IXINITY® (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph

Advances in Hematology, 2016
The goal of these studies was to extensively characterize the first recombinant FIX therapeutic corresponding to the threonine-148 (Thr-148) polymorph, IXINITY (trenonacog alfa [coagulation factor IX (recombinant)]).
Dougald M. Monroe, Richard J. Jenny, Kevin E. Van Cott, Shelly Buhay, Laura L. Saward   +4 more
doaj   +1 more source