Results 71 to 80 of about 12,705,637 (166)

Activated Protein C-catalyzed Proteolysis of Factor VIIIa Alters Its Interactions within Factor Xase [PDF]

Journal of Biological Chemistry, 1996
Factor VIIIa, the cofactor for the factor IXa-dependent conversion of factor X to factor Xa, is proteolytically inactivated by activated protein C (APC). APC cleaves at two sites in factor VIIIa, Arg336, near the C terminus of the A1 subunit; and Arg562, bisecting the A2 subunit (Fay, P., Smudzin, T., and Walker, F. (1991) J. Biol. Chem.
L M, Regan, L M, O'Brien, T L, Beattie, K, Sudhakar, F J, Walker, P J, Fay   +5 more
openaire   +2 more sources

Regional cerebellar structural deficits distinguish psychostimulant‐free ADHD youth with and without familial risk for bipolar I disorder: a cross‐sectional morphometric analysis

Journal of Child Psychology and Psychiatry, EarlyView.
Background Although attention‐deficit/hyperactivity disorder (ADHD) with familial risk for bipolar I disorder (BD) may represent a more severe illness conferring greater risk for developing BD, associated neurostructural substrates remain poorly understood.
Biqiu Tang, L. Rodrigo Patino, Wenjing Zhang, Su Lui, Melissa P. DelBello, Robert K. McNamara   +5 more
wiley   +1 more source

Machine Learning Model for an App‐Based Tool to Assist With the Diagnosis of Canine Atopic Dermatitis

Veterinary Dermatology, EarlyView.
Canine atopic dermatitis (cAD) is a chronic condition requiring life‐long management. Accurate diagnosis can be challenging, with no reliable diagnostic test. This study aimed to generate a simple diagnostic model for cAD. This model is a relevant prototype for an app‐based tool to support general practitioners in the diagnosis of cAD alongside ...
Xavier Langon, Mathieu Montoya, Isabelle Gourdon   +2 more
wiley   +1 more source

Detailed Mechanisms of the Inactivation of Factor VIIIa by Activated Protein C in the Presence of Its Cofactors, Protein S and Factor V*

Journal of Biological Chemistry, 2008
Factor VIIIa is inactivated by a combination of two mechanisms. Activation of factor VIII by thrombin results in a heterotrimeric factor VIIIa that spontaneously inactivates due to dissociation of the A2 subunit.
A. Gale, Thomas J. Cramer, Diana Rozenshteyn, Jason R. Cruz   +3 more
semanticscholar   +1 more source

Intrinsic stability and functional properties of disulfide bond‐stabilized coagulation factor VIIIa variants [PDF]

Journal of Thrombosis and Haemostasis, 2006
The utility of purified coagulation factor (F)VIII for treatment of hemophilia A is limited in part by its instability following activation by thrombin, which is caused by spontaneous dissociation of the A2 domain from the activated FVIII (FVIIIa) heterotrimer.
Gale, A., Radtke, K.-P., Cunningham, M., Chamberlain, D., Pellequer, Jean-Luc, Griffin, J.   +5 more
openaire   +3 more sources

Novel Bioresorbable Bone Wax for Potentiated Hemostasis and Osteogenesis

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The synthesized bioresorbable bone wax material for hemostasis and osteogenesis. The preparation process of the novel resorbable bone wax and its mechanism of accelerating coagulation and promoting osteoregeneration through blood cell aggregation. Abstract Orthopedic surgery faces dual challenges of uncontrolled bleeding and poor bone regeneration at ...
Longbao Feng, Yanbin Lu, Pengyu Fu, Shaojun Li, Pengning She, Yang xiao, Jiaming Ye, Wanqi Li, Shaochuan Li, Wei Xue, Rui Guo   +10 more
wiley   +1 more source

Current difficulties and recent advances in bypass therapy for the management of hemophilia with inhibitors: a new and practical formulation of recombinant factor VIIa

Drug Design, Development and Therapy, 2011
Linda Butros, Koh Boayue, Prasad MathewThe University of New Mexico, Albuquerque, New Mexico, USAAbstract: Bypassing agents are the mainstay of treatment for patients with hemophilia with high-titer inhibitors.
Butros L, Boayue K, Mathew P
doaj  

Emicizumab in the Treatment of Hemophilia A. Characteristics and clinical application

Journal of Education, Health and Sport
Introduction: Hemophilia A is an inherited bleeding disorder caused by a congenital deficiency of factor VIII. It is characterized by a tendency for prolonged and excessive bleeding, both spontaneous and trauma-induced.
Ilona Bednarek, Sylwia Lach, Aleksandra Kowalczyk, Adrian Pączek, Paweł Dyczek, Julia Hofman, Wiktoria Staniszewska, Olaf Jadanowski, Karol Seweryn Błąd   +8 more
doaj   +1 more source

Regional cerebellum volume anomalies and associated cognitive function in children with fetal alcohol spectrum disorders

Alcohol, Clinical and Experimental Research, Volume 50, Issue 1, January 2026.
Prenatal alcohol exposure (PAE) significantly impacts cerebellum development, which may affect cognitive function in fetal alcohol spectrum disorders (FASD). Using an advanced MRI volumetric method that characterizes detailed cerebellum structure, this study identified regional cerebellum volume anomalies in children with FASD age 8–17 years ...
Blake A. Gimbel, Donovan J. Roediger, Kent A. Tuominen, Mary E. Anthony, Alexandra L. Doughty, Abigail M. Ernst, Bryon A. Mueller, Erik de Water, the CIFASD, Jeffrey R. Wozniak   +9 more
wiley   +1 more source

Congo Basin Carbon Cycle Responses to Global Change

Global Change Biology, Volume 32, Issue 1, January 2026.
Understanding the resilience of the Congo Basin carbon cycle in the face of current and future pressures requires a detailed understanding of its response to past and present drivers of change. Building on a pantropical framework of drivers and possible regional mechanisms for resilience, this review provides the first comprehensive assessment of Congo
Sarah Worden, Rong Fu, A. Anthony Bloom, Marijn Bauters, Hans Verbeeck, Temilola Fatoyinbo, Wannes Hubau, Lydie‐Stella Koutika, Steve Kwatcho Kengdo, Sybryn L. Maes, Vincent Medjibe, Nicholas J. Russo, Sassan Saatchi, Le Bienfaiteur Sagang, Thomas B. Smith, Denis J. Sonwa, Pascal Boeckx, Elsa M. Ordway   +17 more
wiley   +1 more source