Results 81 to 90 of about 12,705,637 (166)

From Gene to Enzyme: Multidimensional Decoding of the GGT Molecular Family and Its Clinical Tumor Diagnosis

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Gamma‐glutamyltransferase (GGT) is a membrane‐bound enzyme involved in glutathione metabolism and oxidative stress regulation. Although it is traditionally viewed as a liver function marker, emerging evidence suggests that its aberrant expression is closely associated with tumorigenesis, progression, and therapeutic resistance ...
Fei Wang, Jianshan Yang, Feng Zhu, Xuebing Xu, Junpeng Zhao, Xudong Xie, Xuyang He, Yuxuan Huang, Lirong Zhou, Xiaogang Hu, Xiaomin Lu, Mingbing Xiao   +11 more
wiley   +1 more source

Activation of the Factor VIIIa-Factor IXa Enzyme Complex of Blood Coagulation by Membranes Containing Phosphatidyl-L-serine (*)

Journal of Biological Chemistry, 1996
Factor IXa, a serine protease of blood coagulation, functions at least 100,000 times more efficiently when bound to factor VIIIa on a phospholipid membrane than when free in solution. We have utilized the catalytic activity of the factor VIIIa-factor IXa
G. Gilbert, A. Arena
semanticscholar   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex [PDF]

Structure, 2008
Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca(2+) and two Cu(2+) ions.
Ngo, Jacky Chi Ki, Huang, Mingdong, Roth, David A., Furie, Barbara C., Furie, Bruce   +4 more
openaire   +2 more sources

SAXS analysis of intrinsic tenase complex bound to lipid nanodisc highlights intermolecular contacts between factors VIIIa/IXa [PDF]

, 2021
Kenneth Childers, Shaun C. Peters, Pete Lollar, H. Trent Spencer, Christopher B. Doering, Paul Spiegel   +5 more
openalex   +1 more source

PEG‐23 glyceryl distearate, a multifunctional skin‐supporting material, upregulates the expression of factors associated with epidermal barrier and hydration

International Journal of Cosmetic Science, Volume 47, Issue 6, Page 1056-1069, December 2025.
Polyethylene glycol‐23 glyceryl distearate (GDS‐23) forms niosomes and penetrates the skin. Our results suggest that the pharmacological effects following dermal penetration of GDS‐23 may enhance skin homeostasis by improving barrier function and moisture retention.
Tatsuro Miyoshi, Brian C. Keller, Sui Nakagawa, Takashi Ashino, Satoshi Numazawa   +4 more
wiley   +1 more source

Prevalence, hormonal correlates, severity, and neural basis of neurocognitive impairment in patients with hypothyroidism: Systematic review and meta‐analyses

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract The aims of this review were to assess the associations between neuropsychological test results and thyroid hormone levels, as well as the imaging abnormalities in the brain associated with hypothyroidism. For this systematic review and meta‐analysis, 85 prior studies met the inclusion criteria.
Daniel Pankowski, Kinga Wytrychiewicz‐Pankowska   +1 more
wiley   +1 more source

Untangling sedimentation processes in a deep fjord lake in Labrador: A high‐resolution archive of past environment dynamics at Grand Lake

The Depositional Record, Volume 11, Issue 5, Page 1259-1284, November 2025.
Sedimentological and geochemical characteristics are used to reconstruct sedimentation dynamics and erosional processes. Several rapidly deposited layers are characterised over changing depositional environments during the Late Holocene, from a phase when the lake was connected to the sea to a more stable state conducive to varve formation.
Milena S. Kury, Pierre Francus, Léo Chassiot, Dermot Antoniades, Guillaume St‐Onge, Juliette Girard, Patrick Lajeunesse   +6 more
wiley   +1 more source

On the Synthesis and Reactivity of Potassium Phosphinophosphido Dithioformates

European Journal of Inorganic Chemistry, Volume 28, Issue 31, November 1, 2025.
Sterically hindered potassium phosphinophosphido dithioformates K[TerP(CS2)PR2] (R = iPr, tBu) are synthesized from the conversion of the potassium phosphinophosphides K[TerP–PR2] with CS2. In solution, the dithioformate species rearrange to anionic phosphanylthioketones K[TerPC(=S)–P(S)R2].
Karsten Paul Lüdtke, Axel Schulz, Lilian Sophie Szych   +2 more
wiley   +1 more source

Cytology and Differential Diagnosis of Canine Spindle Cell Lipoma

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
A slowly growing large mass in the gluteal area was present in the gluteal area. Fine needle aspiration was performed, and special stains (oil red) were used. First cytological description of a spindle cell lipoma (confirmed by histopathology). ABSTRACT Benign lipomatous tumours in dogs included the very common lipoma and its rare variants, such as ...
Marta Santos, Ricardo Marcos, João Oliveira, Giancarlo Avallone   +3 more
wiley   +1 more source