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Hereditary factor X deficiency in America survey: impact on quality of life and burden of disease in patients and caregivers. [PDF]

open access: yesBlood Coagul Fibrinolysis
Branchford B   +5 more
europepmc   +1 more source

Factor X Deficiency

Seminars in Thrombosis and Hemostasis, 2009
Factor X (FX) deficiency is a rare, recessively inherited bleeding disorder representing 10% of all rare bleeding diseases and affecting 1 in every 1,000,000 people. Its clinical presentation places FX deficiency among the most severe of the rare coagulation defects, typically including hemarthroses, hematomas, and umbilical cord, gastrointestinal, and
Marzia, Menegatti, Flora, Peyvandi
openaire   +3 more sources

The X factor

Survey of Ophthalmology, 2019
A 45-year-old white woman presented with chronic bilateral, painless, progressive, peripheral vision loss. She was found to have bilateral optic atrophy and nonenhancing multifocal white matter lesions on magnetic resonance imaging of the brain. Cerebrospinal fluid analysis showed an elevated level of myelin basic protein.
Muhammad Musab, Shamim   +3 more
openaire   +2 more sources

Factor X deficiency

Blood Reviews, 2002
Factor X is one of the vitamin K-dependent serine proteases. It plays a crucial role in the coagulation cascade, as the first enzyme in the common pathway of thrombus formation. The gene for factor X maps to the long arm of chromosome 13, approximately 2.8 kb downstream of the factor VII gene.
James, Uprichard, David J, Perry
openaire   +2 more sources

Factor X inhibitors

Expert Opinion on Investigational Drugs, 2003
Factor X plays a central role in coagulation, being the point of convergence of the extrinsic and intrinsic pathways of blood clotting. It may also act as one of the links between the coagulation and inflammatory pathways. These findings suggest that factor X may represent an attractive target for a new antithrombotic drug. Indeed, a factor X inhibitor,
Kiat Tsong, Tan   +2 more
openaire   +2 more sources

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