Results 111 to 120 of about 19,325,472 (304)

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu   +7 more
wiley   +1 more source

Assembly of the Intrinsic Factor X Activating Complex – Interactions between Factor IXa, Factor VIIIa and Phospholipid

open access: yesThrombosis and Haemostasis, 1985
Summary The activation of blood coagulation factor X by factor IXa is strongly stimulated by the non-enzymatic cofactors phospholipid, Ca2+ and activated factor VIII. In this paper we present a method by which we were able to determine binding affinities
G. van Dieijen   +4 more
semanticscholar   +1 more source

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

open access: yesMolecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock   +10 more
wiley   +1 more source

The two-dimensional Jacobian Conjecture and unique factorization [PDF]

open access: yesarXiv, 2016
The two-dimensional Jacobian Conjecture says that a $\mathbb{C}$-algebra endomorphism $F:\mathbb{C}[x,y] \to \mathbb{C}[x,y]$ that has an invertible Jacobian is an automorphism. We show that if a $\mathbb{C}$-algebra endomorphism $F:\mathbb{C}[x,y] \to \mathbb{C}[x,y]$ has an invertible Jacobian and if $v \in \mathbb{C}[F(x),F(y),x]$ is a product of ...
arxiv  

The anticoagulant mechanism of action of heparin in contact-activated plasma: inhibition of factor X activation.

open access: yesBlood, 1985
The effects of heparin on the activation of blood coagulation factors IX and X in contact-activated plasma were determined in the present study. In the presence and absence of 0.5 U/mL heparin, the amounts of factor IX that were cleaved 30 minutes after ...
T. McNeely, M. Griffith
semanticscholar   +1 more source

Blood coagulation factor X mRNA encodes a single polypeptide chain containing a prepro leader sequence.

open access: yesNucleic Acids Research, 1984
Thirty thousand colonies of a bovine liver cDNA library were screened with a mixture of synthetic oligodeoxyribonucleotides coding for bovine factor X. Five positive colonies were identified, and plasmid DNA was isolated.
M. Fung, R. Campbell, R. MacGillivray
semanticscholar   +1 more source

Is grit the ‘X-factor’ for interpreters leaving the profession?

open access: yesTranslation and Interpreting : the International Journal of Translation and Interpreting Research, 2016
This study uses the construct of grit, as measured by the persistence a person has to complete his or her goals, even when barriers are present (Duckworth, Peterson, Matthews, & Kelly, 2007).
Jamie L. McCartney
doaj   +1 more source

Davenport constant of the multiplicative semigroup of the quotient ring $\frac{\F_p[x]}{\langle f(x)\rangle}$ [PDF]

open access: yesarXiv, 2014
Let $\mathcal{S}$ be a finite commutative semigroup. The Davenport constant of $\mathcal{S}$, denoted $D(\mathcal{S})$, is defined to be the least positive integer $d$ such that every sequence $T$ of elements in $\mathcal{S}$ of length at least $d$ contains a subsequence $T'$ with the sum of all terms from $T'$ equaling the sum of all terms from $T ...
arxiv  

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