, 2013 Tesis de la Universidad Alfonso X "El sabio"- Facultad de Farmacia. Programa de Doctorado Ciencias Farmaceúticas. 2013BibliografíaTesis realizada por Gema Muñoz de Mier. Coodirectores: D. Javier Pérez de Diego, D.
Muñoz de Mier, Gema
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Factor IXa and factor X influence factor VIIIa stability and inactivation mechanisms in vitro and in vivo. [PDF]
BloodMorris JJ +7 more
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism. [PDF]
BloodSedzro JC +11 more
europepmc +1 more source
Human coagulation factor X and CD5 antigen-like are potential new members of the zonulin family proteins. [PDF]
Biochem Biophys Res Commun, 2023 Konno T +5 more
europepmc +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Vranckx, Jos (2008), Geloof als geneesmiddel. De vergeten factor X?
Religie & Samenleving, 2009 Lammert Gosse Jansma
doaj +1 more source
Quantitative Structure-Activity Relationship Analysis of Isosteviol-Related Compounds as Activated Coagulation Factor X (FXa) Inhibitors. [PDF]
Nutrients, 2022 Gackowski M +4 more
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source