Results 191 to 200 of about 2,837,867 (233)
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Evaluating Anti-factor X<sub>a</sub> Levels in Patients with Augmented Renal Clearance Receiving Enoxaparin Prophylaxis: An Exploratory Pilot Study. [PDF]
J Res Pharm PractSahraei Z, Eshraghi A, Barati S.
europepmc +1 more source
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Acta Haematologica, 2009
In two patients with the abnormal factor X (factor X Friuli) coagulation disorder a multiple tooth extraction was carried out immediately after the transfusion. X of 4 U of factor X concentrate (Bebulin) equivalent to 2,000 ml of normal plasma. No bleeding was noted. The half-life of the exogeneous component was 30 and 28 h, respectively.
A, Girolami, G, Molaro, L, De Marco
openaire +2 more sources
In two patients with the abnormal factor X (factor X Friuli) coagulation disorder a multiple tooth extraction was carried out immediately after the transfusion. X of 4 U of factor X concentrate (Bebulin) equivalent to 2,000 ml of normal plasma. No bleeding was noted. The half-life of the exogeneous component was 30 and 28 h, respectively.
A, Girolami, G, Molaro, L, De Marco
openaire +2 more sources
Blood Reviews, 2002
Factor X is one of the vitamin K-dependent serine proteases. It plays a crucial role in the coagulation cascade, as the first enzyme in the common pathway of thrombus formation. The gene for factor X maps to the long arm of chromosome 13, approximately 2.8 kb downstream of the factor VII gene.
James, Uprichard, David J, Perry
openaire +2 more sources
Factor X is one of the vitamin K-dependent serine proteases. It plays a crucial role in the coagulation cascade, as the first enzyme in the common pathway of thrombus formation. The gene for factor X maps to the long arm of chromosome 13, approximately 2.8 kb downstream of the factor VII gene.
James, Uprichard, David J, Perry
openaire +2 more sources
Expert Opinion on Investigational Drugs, 2003
Factor X plays a central role in coagulation, being the point of convergence of the extrinsic and intrinsic pathways of blood clotting. It may also act as one of the links between the coagulation and inflammatory pathways. These findings suggest that factor X may represent an attractive target for a new antithrombotic drug. Indeed, a factor X inhibitor,
Kiat Tsong, Tan +2 more
openaire +2 more sources
Factor X plays a central role in coagulation, being the point of convergence of the extrinsic and intrinsic pathways of blood clotting. It may also act as one of the links between the coagulation and inflammatory pathways. These findings suggest that factor X may represent an attractive target for a new antithrombotic drug. Indeed, a factor X inhibitor,
Kiat Tsong, Tan +2 more
openaire +2 more sources
Seminars in Thrombosis and Hemostasis, 2009
Factor X (FX) deficiency is a rare, recessively inherited bleeding disorder representing 10% of all rare bleeding diseases and affecting 1 in every 1,000,000 people. Its clinical presentation places FX deficiency among the most severe of the rare coagulation defects, typically including hemarthroses, hematomas, and umbilical cord, gastrointestinal, and
Marzia, Menegatti, Flora, Peyvandi
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Factor X (FX) deficiency is a rare, recessively inherited bleeding disorder representing 10% of all rare bleeding diseases and affecting 1 in every 1,000,000 people. Its clinical presentation places FX deficiency among the most severe of the rare coagulation defects, typically including hemarthroses, hematomas, and umbilical cord, gastrointestinal, and
Marzia, Menegatti, Flora, Peyvandi
openaire +2 more sources