Results 51 to 60 of about 2,704,633 (236)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Pan-cancer investigation of RFX family and associated genes identifies RFX8 as a therapeutic target in leukemia

Heliyon
Background: Several transcription factors and co-factors are encoded by the RFX (Regulatory Factor X) family (RFX1-8) and associated genes (RFXAP and RFXANK).
Zelong Cui, Yue Fu, Minran Zhou, Huimin Feng, Lu Zhang, Sai Ma, Chunyan Chen   +6 more
doaj   +1 more source

Inhibitory Effect of Triterpenoids from Panax ginseng on Coagulation Factor X

Molecules, 2017
Enzymes involved in the coagulation process have received great attention as potential targets for the development of oral anti-coagulants. Among these enzymes, coagulation factor Xa (FXa) has remained the center of attention in the last decade.
Lingxin Xiong, Zeng Qi, Bingzhen Zheng, Zhuo Li, Fang Wang, Jinping Liu, Pingya Li   +6 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

PROPHYLAXIS FOR INHERITED DEFICIENCY OF FACTOR X (PROTECT-X): A SYSTEMATIC REVIEW

Hematology, Transfusion and Cell Therapy
Introduction: Hereditary factor X (FX) deficiency (FXD) is a rare autosomal recessive bleeding disorder. The reduced or absent plasma FX clotting activity leads to spontaneous hemorrhages or bleeds after minor trauma. FXD severity varies among mild (FX 6%
VJP Ferreira, AF Costa, RM Camelo
doaj   +1 more source

Severe congenital factor X deficiency – An unusual cause of intracranial hemorrhage

Journal of Pediatric Critical Care, 2018
Factor X deficiency is one of the rare inherited coagulation disorders. Symptoms vary from mild to severe with the commonest being epistaxis, gum bleeds and menorrhagia.
T P Vigneshwaran, A R Mullai Baalaaji, S Ashok Kumar, D Ashwath, Thirugnanam Rajasekar   +4 more
doaj   +1 more source

Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload

JACC: Basic to Translational Science, 2020
Summary: Activated factor X is a key component of the coagulation cascade, but whether it directly regulates pathological cardiac remodeling is unclear.
Xinji Guo, PhD, Mikhail A. Kolpakov, MD, PhD, Bahman Hooshdaran, PhD, William Schappell, BS, Tao Wang, MD, PhD, Satoru Eguchi, MD, PhD, Katherine J. Elliott, PhD, Douglas G. Tilley, PhD, A. Koneti Rao, MD, Patricia Andrade-Gordon, PhD, Matthew Bunce, PhD, Chintala Madhu, PhD, Steven R. Houser, PhD, Abdelkarim Sabri, PhD   +13 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source