Results 131 to 140 of about 4,655,222 (236)

Pregnancy Complicated by Hereditary Antithrombin Deficiency: A Case Study and Insights From the Literature

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT A pregnant woman with hereditary antithrombin deficiency was managed with adjusted‐dose LMWH throughout pregnancy, monitoring D‐dimer and anti‐Xa activity, successfully preventing thrombosis and hemorrhage.
Ya Zhao, Jian Yin, Jia Song, Yuqi Zhao, Yanping Zhang   +4 more
wiley   +1 more source

Mesoscale Simulations of Blood Coagulation in Flow and Quiescent Domains Using SDPD

International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 9, September 2026.
Mesoscale simulations show how flow conditions and domain type (flow vs. quiescent) influence thrombin and fibrin dynamics. Changes in Reynolds and Péclet numbers, together with fibrinogen levels, affect both spatial patterns and temporal evolution, highlighting the importance of transport–reaction coupling beyond well‐mixed conditions.
Marina Echeverría Ferrero, Nicolas Moreno, Marco Ellero   +2 more
wiley   +1 more source

From Executor to Orchestrator: The Pharmacology Scientist in the Age of Agentic AI

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 648-662, September 2026.
Drug development productivity has not improved despite five decades of computational advancement, with the probability that a compound entering Phase I achieving regulatory approval remaining near 10%. Each automation wave increased throughput while leaving the interpretive bottleneck intact; scientists continued to formulate questions, evaluate ...
Michael McCoy, Matthew McCoy
wiley   +1 more source

Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang, Wenke Shen, Ping Yang, Dongxue Yang, Yuepeng Cao, Yuping Zhou   +5 more
wiley   +1 more source

The Cancer Immunotherapy Thromboembolism Assessment: A Novel Score for Predicting Thromboembolic Events in Melanoma Patients Treated With Immune Checkpoint Inhibition

International Journal of Cancer, Volume 159, Issue 5, Page 1337-1344, 1 September 2026.
Although immune checkpoint inhibitors (ICI) have transformed metastatic melanoma treatment, thromboembolic events (TEEs) remain a serious complication. Moreover, existing risk assessment models were developed prior to ICI use and lack clinical validation.
Tim Zell, Julian Kött, Noah Zimmermann, Greta Ancker, Alexander T. Bauer, Daniel J. Smit, Glenn Geidel, Julian C. Gerwers, Thomas Renné, Sebastian A. Wohlfeil, Jochen Utikal, Stefan W. Schneider, Christoffer Gebhardt   +12 more
wiley   +1 more source

Clinical utility of rivaroxaban in stroke prevention associated with nonvalvular atrial fibrillation – patient considerations

Journal of Blood Medicine, 2014
Ingo Ahrens, Christoph Bode Heart Center, University of Freiburg, Department of Cardiology and Angiology I, Freiburg, Germany Abstract: The direct factor Xa inhibitor rivaroxaban was the first within the group of orally available direct factor Xa ...
Ahrens I, Bode C
doaj  

A Beginner's Guide to Study the Role of Extracellular Vesicles in Coagulation

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT This guide provides an overview of information that is needed to understand and study the coagulant functions of extracellular vesicles (EVs) in human body fluids. Although EV research has expanded rapidly, the physiological functions of EVs remain incompletely understood, and coagulation is one of the first biological functions that was ...
Rienk Nieuwland, Jillian W. P. Bracht, Joost C. M. Meijers, Johannes Thaler   +3 more
wiley   +1 more source

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang, Yin Zhu, Fang Xu, Yongjing Liu, Yuan Li, Ling Yuan, Liqin Wei, Bo Huang, Yan Chen, Pei Huang, Zuochen Du   +10 more
wiley   +1 more source

Anti-factor Xa levels in obese patients receiving enoxaparin for treatment and prophylaxis indications

, 2018
Linda Tahaineh,1 Sahar M Edaily,1 Shadi F Gharaibeh2 1Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology (JUST), Irbid, Jordan; 2Department of Pharmaceutical Sciences, Faculty of Pharmacy, Jerash University,
Tahaineh L, Edaily SM, Gharaibeh SF
core  

Mixture‐Quantitative Structure–Property Relationship Approaches for Jet Fuel‐Component Blends: A Review

Molecular Informatics, Volume 45, Issue 9, September 2026.
A literature review of QSPR approaches to predict jet fuel properties. It exposes the fundamental principles of QSPR and illustrates pure‐compound QSPR through examples of applications for jet fuel components. Mixture‐QSPR (M‐QSPR) modeling specificities are addressed: mixtures representation, design of descriptors for mixtures, and impact on internal ...
Erik Yeghyan, Benoit Creton, Mickaël Matrat, Gilles Marcou   +3 more
wiley   +1 more source