Antithrombin: Deficiency, Diversity, and the Future of Diagnostics
Mass Spectrometry Reviews, EarlyView.ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt +2 more
wiley +1 more source
Anticoagulant treatment: the end of the old agents?
Swiss Medical Weekly, 2012 New oral anticoagulants used as single target inhibitors of coagulation enzymes have been developed and tested in extensive trial programmes. Results of most of these trials showed non-inferior and/or superior efficacy and safety compared to ...
Lukas Graf, Dimitrios A Tsakiris
doaj +1 more source
Coagulant factor Xa inhibits prostacyclin formation in human endothelial cells. Role of factor V. [PDF]
, 1985 Anjana Sinha +4 more
openalex +1 more source
Regimes and Mechanisms of Inflammation Described by a Reaction–Diffusion System
Mathematical Methods in the Applied Sciences, EarlyView.ABSTRACT Inflammation is a biological response of the immune system to external stimuli such as injury or infection. It plays an important role in various diseases including atherosclerosis, cancer, and neurodegenerative diseases. This work presents a generic inflammation model based on reaction–diffusion equations that describes the concentrations of ...
W. El Hajj, N. El Khatib, V. Volpert
wiley +1 more source
To Explore the Potential Inhibitors against Multitarget Proteins of COVID 19 using In Silico Study [PDF]
arXivThe global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many efforts to find the optimal solution of this pandemic. Progressively, drug repurposing is an emergent and powerful strategy with saving cost, time, and labor ...
arxiv
Pharmacophore and ligand-guided screening of antibacterial leads targeting antibiotic resistance factor in Gram-negative bacteria [PDF]
arXiv, 2018 Pathogenic Gram-negative bacteria have developed resistance to antibiotics due to their ability in creating an envelope on the outer layer of lipooligosaccharides (LOS). The cationic phosphoethanolamine (PEA) decoration of LOS lipid A is regulated by lipid A-PEA transferase (EptA) which may serve as a prominent target for developing new antibiotics ...
arxiv
Xabans as Direct Factor Xa Inhibitors [PDF]
Journal of Bioanalysis & Biomedicine, 2015 Direct factor Xa inhibitors are being used clinically. Clinical trials have shown promise for these compounds as substitutes for the currently administered vitamin K antagonists or low molecular weight heparin. Those trials demonstrated efficacy and safety against warfarin for stroke prevention in atrial fibrillation and against lowmolecular- weight ...
openaire +1 more source
Inhibition Of Human Factor Xa By Various Plasma Protease Inhibitors [PDF]
, 1981 M F Scully +3 more
openalex +1 more source
Factor Xa inhibitors in hemodialysis: OK-for now! [PDF]
Proc (Bayl Univ Med Cent), 2023 Banchs JE.
europepmc +1 more source
Inhibition of the prothrombinase complex on phospholipid vesicles, activated platelets, and red blood cells by a covalently-linked antithrombin-heparin complex [PDF]
, 2013 Prothrombinase is composed of a proteinase, factor Xa (Xa), its cofactor Va (Va), Ca2+ and a zymogen, prothrombin (II), assembled on a phospholipid surface.
Stevic, Ivan
core