Results 151 to 160 of about 655,147 (306)

Reversing factor Xa inhibitors – clinical utility of andexanet alfa

Journal of Blood Medicine, 2017
Scott Kaatz,1 Hardik Bhansali,1 Joseph Gibbs,2 Robert Lavender,3 Charles E Mahan,4 David G Paje5 1Division of Hospital Medicine, 2Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, 3Division of General Internal Medicine, University of ...
Kaatz S, Bhansali H, Gibbs J, Lavender R, Mahan CE, Paje DG   +5 more
doaj  

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Comparison of Factor Iia Inhibitor and Factor Xa Inhibitors on Platelet Reactivity in Patients with Both Atrial Fibrillation and Coronary Artery Disease

, 2023
Kailiang Zheng, Willem L. Bor, Ashley Verburg, Errol W. Aarnink, Benjamin Mahmoodi, Hans Kelder, C. M. Hackeng, Jurriën M. ten Berg   +7 more
openalex   +1 more source

Recent Progressions in Applications of Bioactive Polysaccharides in Food and Health Sciences: A Comprehensive Review

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Polysaccharides play a pivotal role in the development of safe and healthy foods. They ameliorate fatigue, preserve the microflora of the gastrointestinal tract, and provide health for the gut in living organisms. These biopolymers are applied for the fabrication of breakthrough drug delivery systems and potential platforms in regenerative medicine ...
M V N L Chaitanya, Bahjat Alhasso, Wadhah Hasan Alkhazali, Ashok Kumar Bishoyi, Rami Oweis, S. Renuka Jyothi, Rishiv Kalia, Laxmidhar Maharana, Ashish Singh Chauhan, Hayder Naji Sameer, Ahmed Yaseen, Zainab H. Athab, Mohaned Adil, Asghar Narmani, Bagher Farhood   +14 more
wiley   +1 more source

Combined Antithrombin and Heparin Supplementation to Blood for Restoring Heparin Responsiveness After Andexanet Alfa Exposure: An In Vitro Model

eJHaem, Volume 7, Issue 1, February 2026.
ABSTRACT Background: Andexanet alfa, a Gla‐domainless mutant factor Xa (GDXa), reverses oral FXa inhibitors but can cause severe heparin resistance during cardiopulmonary bypass (CPB). Antithrombin (AT) supplementation may mitigate this effect, though dosing evidence is limited. Methods We evaluated in vitro the effectiveness of combined heparin and AT
Amir L. Butt, Hisako Okada, Kofi B. Vandyck, Nana Toyoda, Shinobu Itagaki, Kenneth E. Stewart, Kenichi A. Tanaka   +6 more
wiley   +1 more source

Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors.

New England Journal of Medicine, 2016
Stuart J Connolly, T. Milling, J. Eikelboom, C. Michael, Gibson, J. Curnutte, A. Gold, M. Bronson, Genmin Lu, P. Conley, P. Verhamme, Jeannot Schmidt, S. Middeldorp, Alexander T Cohen, J. Beyer-Westendorf, P. Albaladéjo, J. López-Sendón, S. Goodman, J. Leeds, Brian L. Wiens, Deborah M Siegal, E. Zotova, Brandi Meeks, J. Nakamya, W. Lim, M. Crowther   +25 more
semanticscholar   +1 more source

Tackling High Dimensionality in QSP: Guiding Model Order Reduction With Index Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Quantitative systems pharmacology (QSP) models offer a useful platform to integrate drug pharmacology with knowledge about biological mechanisms across multiple scales and data sources into a unified quantitative framework. This makes them invaluable to address many relevant questions in drug research and development.
Johannes Tillil, Wilhelm Huisinga, Jane Knöchel   +2 more
wiley   +1 more source

The role of factor Xa inhibitors in venous thromboembolism treatment

Vascular Health and Risk Management, 2015
Katherine P Cabral,1 Jack E Ansell2 1Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, NY, USA; 2Hofstra-North Shore/LIJ School of Medicine, Hempstead, NY, USA Abstract: Three factor Xa inhibitors have been studied
Cabral KP, Ansell JE
doaj  

Studies of factor Xa/phospholipid-induced intravascular coagulation in rabbits. Effects of immunodepletion of tissue factor pathway inhibitor. [PDF]

, 1993
B J Warn-Cramer, S I Rapaport
openalex   +1 more source

Keratinocyte‐Associated Biomarkers Reveal Pathogenic Mechanisms in Acne

FASEB BioAdvances, Volume 8, Issue 2, February 2026.
The study workflow integrates scRNA‐seq and bulk RNA‐seq data to characterize acne pathogenesis. Step 1 identifies expanded keratinocyte populations using single‐cell analysis. Step 2 filters candidate genes via WGCNA and differential expression integration.
Sini Cai, Yinjing Lin, Heng Xie, Xian Ao, Qiwei Liu, Lining Huang   +5 more
wiley   +1 more source