Results 151 to 160 of about 4,655,222 (236)

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, Volume 117, Issue 9, Page 2567-2585, September 2026.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source

Rational Design of Novel Isosteviol-Derived Factor Xa Inhibitors Using Integrated QSAR, Molecular Docking, Molecular Dynamics, and MM/GBSA Analyses. [PDF]

Biology (Basel)
Gordon P, Szeleszczuk Ł, Lasota M, Pisklak DM, Gackowski M.   +4 more
europepmc   +1 more source

Early Bleeding Risk After DOAC Initiation With Concomitant Amiodarone in Older Adults With Atrial Fibrillation

Journal of Cardiovascular Electrophysiology, Volume 37, Issue 9, Page 2119-2121, September 2026.
ABSTRACT Background Amiodarone is frequently co‐prescribed with direct oral anticoagulants (DOACs) in atrial fibrillation (AF), but its impact on early bleeding risk after DOAC initiation in older adults remains uncertain. We evaluated short‐term safety outcomes associated with concomitant amiodarone use at the time of DOAC initiation.
Isadora D. Guarino, Saman Nazarian
wiley   +1 more source

Small-Molecule Factor Xa Inhibitors: Translational SAR, Assay-Aware Data Quality, and QSAR-Readiness for CADD-Oriented Discovery. [PDF]

Pharmaceuticals (Basel)
Gordon P, Janiak M, Mądra-Gackowska K, Wydeheft L, Hołyńska-Iwan I, Gackowski M.   +5 more
europepmc   +1 more source

MgCBP1 Synergistically Enhances MgENG2‐Mediated Cellulose Degradation to Promote Parasitism in Meloidogyne graminicola

Molecular Plant Pathology, Volume 27, Issue 9, September 2026.
A cellulose‐binding protein (MgCBP1) and a β‐1,4‐endoglucanase (MgENG2) from Meloidogyne graminicola act synergistically. MgCBP1 binds cellulose, disrupts fibre structure and enhances MgENG2‐mediated cellulose degradation via its cellulose‐binding module. This cooperative action promotes nematode infection, providing the first evidence of CBP–cellulase
Chunhui Huang, Yuqing Cao, Ao Xu, Jiani Chen, Borong Lin, Qiuling Huang, Kan Zhuo   +6 more
wiley   +1 more source

From knowledge graph to topological data analysis: a novel framework to analyze gene regulatory networks for tomato–multi‐pathogen interactions

New Phytologist, Volume 251, Issue 5, Page 3039-3055, September 2026.
GENIAL framework. Summary of the main steps of the framework to infer and analyze GRN. Summary Tomato (Solanum lycopersicum), despite being the most important vegetable crop world‐wide, remains vulnerable to over 200 diseases caused by different pests.
Maxime Multari, Mathieu Carrière, Xavier Amorós‐Gabarrón, Krishna Kumar, Pratila Debnath, Alexina Damy, Ludo Andrianirina Mamisoa, Sebastian Lobentanzer, Julio Saez‐Rodriguez, Stéphanie Jaubert, Aurélien Dugourd, Justyna J. Olas, Silvia Bottini   +12 more
wiley   +1 more source

Hospital Course and Outcomes After Major Bleeding in Patients on Factor Xa Inhibitors in Japan: A Nationwide Observational Study. [PDF]

J Atheroscler Thromb
Kohsaka S, Yasaka M, Hoshino M, Ide R, Wada F, Morita N.   +5 more
europepmc   +1 more source

Attachment insecurity and psychological (mal)adjustment in older adults: The longitudinal role of fear of self‐compassion

Psychology and Psychotherapy: Theory, Research and Practice, Volume 99, Issue 3, Page 931-945, September 2026.
Abstract Objectives Insecure attachment has been suggested to precede and perpetuate fear of self‐compassion, with a negative impact on mental health. However, this evidence was obtained using general‐age samples and cross‐sectional designs. Our objective was to, in an older adult sample, analyse longitudinally the indirect effect of fear of self ...
Lúcia Tavares, Paula Vagos, Ana Xavier
wiley   +1 more source

The 5 most frequently asked questions about factor Xa inhibitors. [PDF]

Hematology Am Soc Hematol Educ Program, 2022
Wang TF, Carrier M.
europepmc   +1 more source

Calibration-free electrochemical sensor to monitor factor-Xa inhibitors at the point-of-care anticoagulation therapy

Calibration-free electrochemical sensor to monitor factor-Xa inhibitors at the point-of-care anticoagulation ...
Angel Torriero (13058478), Ashwin KV Mruthunjaya (14394558), Ronald C Chatelier (15855812)   +2 more
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