(R)-3-amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding mode
A putative nonsubstrate like binding mode of (R)-3- amidinophenylalanine derivatives to factor Xa, as derived from modeling experiments based on Xray analysis of their complexes with trypsin, was used to design a new generation of inhibitors.
Bode, W. +4 more
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Peak and Trough Concentration Ranges of Factor Xa Inhibitors for Preventing Thromboembolic Stroke in Korean Patients with Non-valvular Atrial Fibrillation. [PDF]
Park JS +5 more
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Platelet-rich fibrin ensures hemostasis after single-tooth removal under factor Xa inhibitors - a clinical prospective randomized split-mouth study. [PDF]
Kyyak S +4 more
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Impact of Factor Xa inhibitors on cardiovascular events in older patients with nonvalvular atrial fibrillation. [PDF]
Takahashi M +7 more
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Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of deep vein thrombosis. [PDF]
Wang X +11 more
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Endovascular Stenting and Factor Xa Inhibitors for Filter-Associated Chronic IVC Occlusion: A Case Series. [PDF]
Cao P +6 more
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Effect of PCC on Thrombin Generation among Patients on Factor Xa Inhibitors with Major Bleeding or Needing Urgent Surgery (GAUGE): Design and Rationale. [PDF]
Shaw JR +9 more
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Adverse Events of Factor Xa Inhibitors in Pediatric Patients: A Meta-analysis and Pharmacovigilance Study. [PDF]
Chong S +5 more
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The efficacy and safety of direct factor Xa inhibitors versus vitamin K antagonists for atrial fibrillation in patients on hemodialysis: a meta-analysis of randomized controlled trials. [PDF]
Abuelazm M +6 more
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Factor Xa inhibitors versus vitamin K antagonist in morbidly obese patients with venous thromboembolism: a systematic review and meta-analysis. [PDF]
Park DY, An S, Arif AW, Sana MK, Vij A.
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