Results 171 to 180 of about 788,607 (367)

Direct oral anticoagulant blood level monitoring in daily practice

Thrombosis Update, 2021
Introduction: Routine monitoring is not required in direct oral anticoagulant (DOAC) treatment, yet it is frequently performed. Guidance on the interpretation and management of DOAC level measurements is lacking and it is key to investigate which ...
R. Bavalia, J.E. Veenhuizen, R.C.C. Hengeveld, D. Braeken, A.J.W. Gulpen, H. Ten Cate, S. Middeldorp, Y.M.C. Henskens, B.A. Hutten, M. Coppens, A.K. Stroobants   +10 more
doaj  

A unified multi‐scale method for simulating immersed bubbles

Computer Graphics Forum, EarlyView.
Abstract We introduce a novel unified mixture‐based method for simulating underwater bubbles across a range of bubble scales. Our approach represents bubbles as a set of Lagrangian particles that are coupled with the surrounding Eulerian water volume. When bubble particles are sparsely distributed, each particle, typically smaller than the liquid grid ...
Joel Wretborn, Alexey Stomakhin, Christopher Batty   +2 more
wiley   +1 more source

Serine 380 (P14) → Glutamate Mutation Activates Antithrombin as an Inhibitor of Factor Xa [PDF]

, 2000
Akiko Futamura, Peter G.W. Gettins
openalex   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

RBM39 Promotes Base Excision Repair to Facilitate the Progression of HCC by Stabilising OGG1 mRNA

Cell Proliferation, EarlyView.
Targeting RBM39 attenuates BER via destabilising OGG1 mRNA and potentiates KBrO3‐induced oxidative stress in HCC. Our study represents a valuable treatment strategy combining indisulam and an oxidative stress inducer in HCC. ABSTRACT Targeting base excision repair (BER) has been an attractive strategy in cancer therapeutics.
Hongda An, Anliang Xia, Siyuan Liu, Dongjun Luo, Longpo Geng, Binghua Li, Beicheng Sun, Zhu Xu   +7 more
wiley   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, EarlyView.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

Stabilization of the catalytically active structure of a molybdenum‐dependent formate dehydrogenase depends on a highly conserved lysine residue

The FEBS Journal, EarlyView.
Molybdenum‐dependent formate dehydrogenases (Mo‐FDHs) contain a strictly conserved lysine residue (K44) in the vicinity of an electron‐transferring [4Fe‐4S] cluster and a catalytically active molybdenum atom coordinated by two molybdopterins (MPT‐1 and MPT‐2).
Feilong Li, Michael Lienemann
wiley   +1 more source

Reversing factor Xa inhibitors – clinical utility of andexanet alfa

Journal of Blood Medicine, 2017
Scott Kaatz,1 Hardik Bhansali,1 Joseph Gibbs,2 Robert Lavender,3 Charles E Mahan,4 David G Paje5 1Division of Hospital Medicine, 2Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, 3Division of General Internal Medicine, University of ...
Kaatz S, Bhansali H, Gibbs J, Lavender R, Mahan CE, Paje DG   +5 more
doaj  

Global Comparative Antithrombin Field Study: Impact of Laboratory Assay Variability on the Assessment of Antithrombin Activity Measurement at Fitusiran Clinical Decision‐Making Points

Haemophilia, EarlyView.
ABSTRACT Introduction Fitusiran is a subcutaneous, investigational small interfering RNA therapeutic that lowers antithrombin (AT) to increase thrombin generation and rebalance haemostasis in people with haemophilia A or B with or without inhibitors.
Ekta Seth Chhabra, Ali Sadeghi‐Khomami, Mingjie Liu, Guy Young, Steven W. Pipe, Margareth C. Ozelo, Cecile Le Camus, Myew‐Ling Toh, Marek Demissie, Flora Peyvandi   +9 more
wiley   +1 more source

Antithrombotic properties of a direct thrombin inhibitor with a prolonged half-life and AT-mediated factor Xa inhibitory activity [PDF]

, 2003
G.M.T. Vogel, D.G. Meuleman, Theo G. van Dinther, Rogier C. Buijsman, A. Princen, Martine J. Smit   +5 more
openalex   +1 more source