Results 71 to 80 of about 18,017 (247)

Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin

, 1995
Crystal structures of DX9065a and a related bisamidino-aryl inhibitor specific for the blood-clotting factor Xa have been solved in complex with bovine β-trypsin to a resolution of 1.9 Å.
Huber, Robert, Bode, Wolfram, Robert Huber, Stubbs, Milton T., Milton T. Stubbs, Wolfram Bode   +5 more
core   +1 more source

The Role of Factor Xa-Independent Pathway and Anticoagulant Therapies in Cancer-Related Stroke

, 2021
Background: The optimal strategy for stroke prevention in cancer patients is unknown. We compared the underlying mechanisms of coagulopathy and the effects of anticoagulants in patients with active cancer and atrial fibrillation (AF).
Hee-Jin Kim, Myung-Ju Ahn, Oh Young Bang, Yeon Hee Cho, Jaechun Hwang, Hyung Jun Kim, Jong-Won Chung, Yun Jeong Lim, Woo-Keun Seo, Gyeong-Moon Kim   +9 more
core   +1 more source

Perfluorohexanone for Clean Fire Suppression: Mechanisms, System Design, Applications, and Future Directions

Safety Science and Technology, EarlyView.
Driven by halon and high GWP agent phase out, perfluorohexanone is increasingly deployed in enclosures such as data centers, marine machinery spaces, and industrial process lines. This review summarizes application performance, discharge and distribution design, material compatibility, and byproduct control and maps practical gaps for large volume and ...
Zhilei Yu, Haibin Dong, Yanfeng Sheng, Xuelei Xian, Dehua Zhang, Feiran Li, Liang Liu, Junchao Zhao, Heping Zhang   +8 more
wiley   +1 more source

Influence of patient factors on target plasma volume treated attainment rate during double filtration plasmapheresis in patients with hypertriglyceridemic acute pancreatitis

Therapeutic Apheresis and Dialysis, EarlyView.
Abstract Introduction This study aims to investigate patient factors affecting the rate of plasma volume target attained in hypertriglyceridemic pancreatitis (HTG‐AP) patients undergoing double filtration plasmapheresis (DFPP). Methods A retrospective analysis of 82 HTG‐AP‐interpreted patients from January 2019 to April 2024 compared target plasma ...
Hui Zhang, Chenqiang Zhu, Yunlong Wu
wiley   +1 more source

Real-world andexanet alfa utilization and the association between delay in administration due to hospital transfer and all-cause inpatient mortality

Research and Practice in Thrombosis and Haemostasis
Background: Evaluations of andexanet alfa for the reversal of factor Xa inhibitor-associated bleeding have been small, with cohorts drawn from single/limited sites.
Huiqiao Fan, Youssef Bessada, Craig I. Coleman   +2 more
doaj   +1 more source

Peri‐operative management of diabetes mellitus: a multidisciplinary consensus statement from the Association of Anaesthetists and the Joint British Diabetes Societies for Inpatient Care group

Anaesthesia, EarlyView.
Summary Introduction Surgery in patients with diabetes mellitus is associated with increased morbidity and mortality compared with those who do not have diabetes mellitus. This is likely multifactorial and could be attributed to organisational issues; dysglycaemia; hospital‐acquired diabetic ketoacidosis; errors with insulin prescribing and ...
Nicholas A. Levy, Kariem El‐Boghdadly, Dileep N. Lobo, Daniel J. Stubbs, Parizad Avari, Donal Buggy, Claire Frank, Kim Howson, Jinty Moffett, Emma Morris, Omar G. Mustafa, Glynn Nash, Pádraig Ó Scanaill, Sarah Procter, Gerry Rayman, Kim Russon, Caroline Thomas, Sarah Tinsley, Allan Xu, Ketan Dhatariya   +19 more
wiley   +1 more source

Velhos e novos anticoagulantes orais. Perspetiva farmacológica

Revista Portuguesa de Cardiologia, 2012
Resumo: A terapêutica anticoagulante oral está em mudança. A varfarina e o acenocumarol constituem ainda o padrão anticoagulante oral em muitos contextos clínicos.
Pedro Marques da Silva
doaj   +1 more source

DX‐9065a, a Direct Inhibitor of Factor Xa [PDF]

Cardiovascular Drug Reviews, 2003
ABSTRACTThe synthetic compound DX‐9065a represents a low molecular weight, direct, competitive inhibitor of factor Xa (FXa) with a high affinity and selectivity for the enzyme. Under experimental conditions DX‐9065a exerts strong anticoagulant actionsin vitroandin vivoand is antithrombotically effective in various thrombosis models.
openaire   +2 more sources

Effect of Factor Xa Inhibitors on the Platelet-derived Microparticles Procoagulant Activity In Vitro> and In Vivo in Rats

, 2000
SummaryThe aim of this study was to investigate the effect of factor Xa inhibitors on the prothrombinase activity of platelet-derived microparticles in vitro and in vivo.
J. P. Hérault, B. Perrin, C. Jongbloet, A. Bernat, A. M. Pflieger, J. M. Herbert   +5 more
core   +1 more source

Anticoagulation Strategies in Adults Undergoing Extracorporeal Membrane Oxygenation: A Systematic Review and Meta‐Analysis

Artificial Organs, EarlyView.
In this meta‐analysis of 2 775 adult ECMO patients from non‐randomized studies, direct thrombin inhibitors and low‐molecular‐weight heparins demonstrated a favorable efficacy and safety profile over unfractionated heparin. These findings suggest them to be effective alternatives to unfractionated heparin, underscoring the urgent need for randomized ...
Vincenz Scharner, Karoline Lenz, Harald Herkner, Nina Buchtele, Thomas Staudinger, Eva Schaden, Marion Wiegele, Johannes Gratz   +7 more
wiley   +1 more source