Results 121 to 130 of about 2,109,479 (260)

High‐Index, Low‐Loss Optical Material Platforms for Ultra‐Broadband Ultraviolet‐to‐Visible Achromatic Metalenses

Advanced Functional Materials, EarlyView.
An integrated material platform combining engineered SiNx thin films and printable ZrO2 nanoparticle‐embedded resin enables broadband achromatic metalenses from the ultraviolet to visible range. The demonstrated meta‐optics achieve near‐diffraction‐limited focusing with minimal chromatic aberration.
Hyunjung Kang, Dongmin Jeon, Eunji Lee, Junsuk Rho   +3 more
wiley   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Mapping Nanoscale Protein‐Corona Kinetics of DoE‐Optimized Perfluorocarbon Encapsulated‐PLGA Nanoparticles by In Situ, Time‐Resolved Synchrotron SAXS

Advanced Healthcare Materials, EarlyView.
A two‐phase workflow (OFAT screening followed by central composite design) maps how processing variables tune PFCE‐PLGA nanoparticle size, dispersity, surface charge, loading, and 19F‐MRI signal. In situ, time‐resolved synchrotron SAXS tracks albumin‐corona growth on intact dispersions and reveals PFCE‐dependent adsorption pathways.
Joice Maria Joseph, Maria Rosa Gigliobianco, Cristina Minnelli, Paolo Moretti, Francesco Spinozzi, Giovanna Mobbili, Sara Pistolesi, Cristina Casadidio, Gabriella Teti, Roberta Censi, Stefano Antonio Gattone, Piera Di Martino   +11 more
wiley   +1 more source

The contact pathway and sepsis

Research and Practice in Thrombosis and Haemostasis, 2019
The contact pathway factors XI (FXI) and XII (FXII) have been demonstrated to be largely dispensable for hemostasis, as their absence results in a mild to absent bleeding diathesis. A growing body of literature, however, suggests that the contact pathway
Vikram Raghunathan, Jevgenia Zilberman‐Rudenko, Sven R. Olson, Florea Lupu, Owen J. T. McCarty, Joseph J. Shatzel   +5 more
doaj   +1 more source

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source

Factor XI inhibitors in cancer-associated venous thromboembolism: what’s next?

Bleeding, Thrombosis and Vascular Biology
Venous thromboembolism (VTE) is an important cause of morbidity and mortality in individuals with active cancer. Most cancer-associated VTE occurs in the ambulatory setting in individuals receiving systemic therapy. Multiple anticoagulants are currently
Hiranya M. Dave, Mehrie H. Patel, Keith R. McCrae, Alok A. Khorana   +3 more
doaj   +1 more source

Coagulation factor XI and coronary artery disease: is there room for factor XI inhibitors?

Polish Archives of Internal Medicine
A growing body of evidence indicates that coagulation factors may exhibit not only prothrombotic but also proatherogenic effects. Recent years have yielded numerous animal studies demonstrating that factor (F) XI, largely genetically determined, which constitutes a junction between the tissue factor-dependent coagulation and contact pathways, may ...
Elżbieta, Paszek, Anetta, Undas
openaire   +2 more sources

Water Permeates and Plasticizes Amorphous Carbon Dots: Unraveling the Inner Accessibility of the Nanoparticles by Glass Transition Studies

Advanced Materials, EarlyView.
The water permeability of amorphous carbon dots (CDs) is demonstrated by investigating their plasticization. Novel polyamide‐based and amorphous nanoparticles are synthesized by controlling their inner packing density. Water plasticization is evidenced by the decrease of the CDs glass transition temperature with increasing the hydration degree.
Elisa Sturabotti, Valerio Di Lisio, Lucia Cardo, Alessandro Camilli, Estela Moretón Alfonsín, Daniele Cangialosi, Amaia Iturrospe Ibarra, Arantxa Arbe, Maurizio Prato   +8 more
wiley   +1 more source

Three Factor 11 Mutations Associated with Factor XI Deficiency in a Turkish Family

Turkish Journal of Hematology, 2018
Veysel Sabri Hançer, Zafer Gökgöz, Murat Büyükdoğan   +2 more
doaj   +1 more source

A Quantum Interior Point Method for LPs and SDPs

, 2018
We present a quantum interior point method with worst case running time $\widetilde{O}(\frac{n^{2.5}}{\xi^{2}} \mu \kappa^3 \log (1/\epsilon))$ for SDPs and $\widetilde{O}(\frac{n^{1.5}}{\xi^{2}} \mu \kappa^3 \log (1/\epsilon))$ for LPs, where the output
Kerenidis, Iordanis, Prakash, Anupam
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