Results 141 to 150 of about 14,789,955 (251)

A site on factor XII required for productive interactions with polyphosphate. [PDF]

J Thromb Haemost, 2023
Shamanaev A, Litvak M, Cheng Q, Ponczek M, Dickeson SK, Smith SA, Morrissey JH, Gailani D.   +7 more
europepmc   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Clinical heterogeneity in congenital factor XII deficiency: Coexisting risk factors in thrombotic and bleeding events. [PDF]

Br J Haematol
Qu X, Jia Y, Wang Y, Xue F, Liu W, Chen Y, Ju M, Sun T, Dai X, Dong H, Gu W, Zhang A, Sun Q, Xiao Z, Yang R, Zhang L, Liu X, Fu R.   +17 more
europepmc   +1 more source

Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI. [PDF]

Case Rep Hematol, 2023
Beck PJ, Benfield J, Morales J.
europepmc   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Severe Factor XII Deficiency in a Patient with Spontaneous Coronary Artery Dissection. [PDF]

Int J Mol Sci
Zormpa A, Nomikou EG, Kalantzis D, Apergis G, Zouganeli V, Pavlou EG, Mavridou D, Katsadiotis G, Rallidis LS, Kokoris S.   +9 more
europepmc   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Coagulation factor XII deficiency alleviates vascular dysfunction and cognitive impairment in a mouse model of cerebral β-amyloidosis and cerebral amyloid angiopathy. [PDF]

Aging Brain
Rouault M, Kindler DR, Ni R, Liberale L, Seiler R, Ielacqua GD, Nitsch R, Pryce C, Camici GG, Kulic L, Klohs J.   +10 more
europepmc   +1 more source

A demonstration of factor XI contributing to hemostasis in the absence of factor XII. [PDF]

Res Pract Thromb Haemost, 2022
Mohammed BM, Cheng Q, Gailani D.
europepmc   +1 more source

Dipolar Coupling Errors in Nuclear Spin Qubits

Advanced Science, EarlyView.
Multi‐nuclear spin registers of phosphorus‐atom qubits in silicon have demonstrated 99.99% single and >$>$99.9% two qubit gate fidelities. Despite nanometer separation, read‐out fidelities between individual nuclear spins within the register are not identical.
I. D. Thorvaldson, P. Macha, J. Reiner, S. H. Misha, Y. Chung, L. Kranz, D. Keith, S. Monir, D. Poulos, S. Sutherland, Y.‐L. Hsueh, B. Thorgrimsson, R. Rahman, J. G. Keizer, S. K. Gorman, M. Y. Simmons   +15 more
wiley   +1 more source