Results 151 to 160 of about 2,447,627 (312)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

[Response to comment on the article "Incidence and factors associated with delirium in an Emergency Department"]. [PDF]

Rev Med Inst Mex Seguro Soc
Ayón-Aguilar J, Serrano-Vértiz L, Quiroz-Lara FV, Torres-Macotela M.   +3 more
europepmc   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

[Anti-obesity drugs and potential changes in the epidemiology of this condition and in cardiovascular risk factors]. [PDF]

Aten Primaria
Cuatrecasas G.
europepmc   +1 more source

Factor Xa; thrombin (factor IIa; F2); factor IXa; factor VIIa/tissue factor complex [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

[Social pain: a clinically relevant literature review in primary care]. [PDF]

Aten Primaria
Ordóñez Azuara YG, Gutiérrez Herrera RF, Hernandez González R, Jasso Castillo MG.   +3 more
europepmc   +1 more source

Inversiones en enseñanza y condiciones macroeconómicas: investigación micro-macro de América Latina y el Caribe [PDF]

(Disponible en idioma inglés únicamente) La enseñanza es un factor sumamente importante del desarrollo económico. Hay un gran cúmulo de obras empíricas publicadas sobre los factores que determinan el logro en la enseñanza.
Jere R. Behrman, Miguel Székely, Suzanne Duryea   +2 more
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