Results 201 to 210 of about 72,175 (268)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Barriers to the prevention of violence against children identified by healthcare professionals: a scoping review. [PDF]

Rev Esc Enferm USP
Rodrigues JRGDV, Luz SV, Custódio SMR, Pastorinho AIDS, Santos SQ, Caldeira ASL, Ramos-Pichardo JD, Barbieri-Figueiredo MDC.   +7 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

[Clinical coordination and strengthening of primary care for cancer diagnosis in Latin America: a scoping reviewCoordenação clínica e fortalecimento da atenção primária no diagnóstico do câncer na América Latina: revisão de escopo]. [PDF]

Rev Panam Salud Publica
Luer-Aguila R, Oliver-Anglès A, Vázquez ML, Vargas I.   +3 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

[Nutritional and sedentary habits associated with suicidal behavior in Argentine adolescents: CHAID decision tree] [PDF]

Rev Fac Cien Med Univ Nac Cordoba
Guevara Tirado A.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

[Barriers and facilitators to accessing healthcare during the pandemic: an assessment of healthcare managers and professionals]. [PDF]

Aten Primaria
Bengoa-Urrengoechea I, Aguilar-Palacio I, Valero-Errazu D, Rabanaque MJ, Gómez-Poyato MJ, Sánchez-Calavera MA, Malo S.   +6 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

[Planetary Health from a prevention and health promotion perspective]. [PDF]

Aten Primaria
Del Campo Giménez M, Gallor Bohórquez H, Egea-Ronda A, Camarelles Guillem F, Jiménez Ochando L.   +4 more
europepmc   +1 more source