Results 61 to 70 of about 4,323 (252)
Análisis de los factores determinantes de la cultura organizacional en el ambiente empresarial
Entramado, 2014 El presente artículo muestra el análisis de los factores determinantes de la cultura organizacional en el ambiente empresarial y la incidencia de estos condicionantes del entorno en los cambios internos y el comportamiento de colaboradores y directivos ...
José Morelos-Gómez +1 more
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Los determinantes de las políticas públicas: ¿los “factores políticos” importan ?
Revista del Instituto Electoral del Estado de México. Apuntes Electorales, 2018 Sin Resumen para Los determinantes de las políticas públicas: ¿los “factores políticos” importan ?
Marta Romero de la Cruz
doaj
On Bipartite Almost Bipartite Graphs and the Determinantal Factorization
A graph is almost bipartite if it contains exactly one odd cycle, and it is Konig-Egervary if the sum of the independence number and the matching number equals the order of the graph. We introduce the class of Bipartite-Almost Bipartite graphs (BAB-graphs), defined through a controlled union of a bipartite graph and several almost bipartite non-Konig ...
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
FACTORES DETERMINANTES DE LA MOTIVACIÓN EMPRENDEDORA
Mikarimin. Revista Científica Multidisciplinaria. e-ISSN 2528-7842, 2019 Esta investigación postula a través de una revisión de la literatura que los factores determinantes de la motivación emprendedora, suelen provenir de 2 tipos de factores: (1) cognitivos y (2) sociales/ambientales. Con este antecedente, se examina la capacidad de estos dos factores, representados a través de 3 variables, para predecir la motivación ...
Terán Yépez, Eduardo +1 more
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source