Results 51 to 60 of about 912,839 (341)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Properties of the Methanol Soluble Factor Required by the Mink.

Experimental Biology and Medicine, 1950
SummaryThe methanol extract factor required by the mink has been found to be soluble in 90% phenol and insoluble in acetone, n-butanol and 3/4 saturated ammonium sulfate.Fish solubles contain this factor, but dried distillers solubles, dried whey, pork spleen, and hog intestinal mucosa were found to be inactive.The relationship between the methanol ...
S B, TOVE, R J, LALOR, C A, ELVEHJEM
openaire   +2 more sources

FACTORES MOTIVACIONALES PARA LA CONCLUSIÓN DE UNA CARRERA UNIVERSITARIA [PDF]

, 2013
Esta investigación cualitativa de diseño fenomenológico se centra en los factores motivacionales que vivenciaron los estudiantes de Ciencias Contables de la cohorte 2007 – 2011 de la Universidad Tecnológica Intercontinental de Fernando de la Mora, para ...
Silvero, Mirtha Alfonso de
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

CALIDAD DE LA EDUCACIÓN SUPERIOR: PERCEPCIONES DE LOS ESTUDIANTES UNIVERSITARIOS ARGENTINOS [PDF]

, 2014
La universidad pública es un agente educativo, social y económico de primer orden en la sociedad del conocimiento. Las universidades son probablemente las instituciones que mayor impacto y valor añadido aportan a su territorio, ya sea por la vía de la ...
Colombo, María de la Paz, Gabriela Fernanda Mollo Brisco, Martín López Armengol, Juan José Gilli, Gilli, Juan José, María Paz Andreasen, Andreasen, María Paz, López Armengol, Martín Aníbal, María de la Paz Colombo, Armengol, Martín López, Brisco, Gabriela Fernanda Mollo, Mollo Brisco, Gabriela Fernanda   +11 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Influencia de la temperatura en la composición de los racimos de Vitis vinifera L. cv Pinot Noir expuestos al este y al oeste, en distintos estados de madurez

RIA: Revista Investigaciones Agropecuarias, 2012
Los componentes de las bayas (peso, azúcares, ácidos, polifenoles) están influenciados por el microclima de la canopia y por el estado de madurez de éstas, entre otros factores.
M. GALLINA
doaj  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Diversidad fenotípica de veinte accesiones promisorias de mangos criollos y comerciales introducidas en Colombia

Biotecnología en el Sector Agropecuario y Agroindustrial
La alta variabilidad genética es una de las consecuencias de los procesos de adaptación de las especies ante factores abióticos y bióticos extremos, lo cual contribuye a asegurar su persistencia frente a posibles riesgos. Colombia tiene establecidos más
Martha del Pilar López Hernández , Angelica Piedad Sandoval Aldana, Jairo García Lozano, Jorge Alberto Valencia Montoya   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source