Results 281 to 290 of about 12,781,850 (371)

Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery

Med Research, EarlyView.
The integration of AI/ML into nanomedicine offers a transformative approach to therapeutic design and optimization. Unlike conventional empirical methods, AI/ML models (such as classification, regression, and neural networks) enable the analysis of complex clinical and formulation datasets to predict optimal nanoparticle characteristics and therapeutic
Rohan Chand Sahu, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal   +3 more
wiley   +1 more source

Effects of Sodium Bicarbonate Ringer's Solution Combined with Positive End-Expiratory Pressure on the Internal Environment of Patients Undergoing Bariatric Surgery: A Randomized 2 × 2 Factorial Design Pilot. [PDF]

Obes Surg
Jiang X, Wang R, Guo L, Shan Z, Wang Z.
europepmc   +1 more source

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abundantly expressed in MSNs, is a promising biomarker of striatal integrity, but region‐specific associations and its potential for early‐stage ...
Mena Farag, Michael J. Murphy, Nicola Z. Hobbs, Michela Leocadi, Kate Fayer, Olivia Thackeray, Johan Gobom, Marc Ciosi, Amanda Heslegrave, Henrik Zetterberg, Douglas R. Langbehn, Darren G. Monckton, Edward J. Wild, Sarah J. Tabrizi, Rachael I. Scahill   +14 more
wiley   +1 more source

Analysis of a Modified Version of the Inventory of Non‐Ataxia Signs Over 12 Years in Patients with Friedreich's Ataxia in the EFACTS Study

Movement Disorders, EarlyView.
Abstract Background Friedreich's ataxia is a rare, neurodegenerative, multisystem disorder. While ataxia is a hallmark, non‐ataxia signs, including muscle weakness, spasticity, and dysphagia are equally disabling. The Inventory of Non‐Ataxia Signs (INAS) is a symptom list transformable to a 16‐item count.
Stella Andrea Lischewski, Imis Dogan, Paola Giunti, Michael H. Parkinson, Caterina Mariotti, Alexandra Durr, Claire Ewenczyk, Sylvia Boesch, Wolfgang Nachbauer, Thomas Klopstock, Claudia Stendel, Francisco Javier Rodríguez de Rivera Garrido, Ludger Schöls, Zofia Fleszar, Thomas Klockgether, Marcus Grobe‐Einsler, Ilaria Giordano, Myriam Rai, Massimo Pandolfo, Heike Jacobi, Ralf‐Dieter Hilgers, Jörg B. Schulz, Kathrin Reetz, on behalf of the EFACTS Study Group   +23 more
wiley   +1 more source

Extraction Optimization of Quercus cerris L. Wood Chips: A Comparative Study between Full Factorial Design (FFD) and Artificial Neural Network (ANN). [PDF]

Antioxidants (Basel)
Ponticelli M, Carlucci V, Mecca M, Todaro L, Milella L, Russo D.   +5 more
europepmc   +1 more source

Optimization of in vivo antimalarial efficacy of combinations of aqueous leaf extracts of Artemisia annua L., Vernonia amygdalina Del, and Microglossa pyrifolia (Lam.) Kuntze using factorial design. [PDF]

BMC Complement Med Ther
Angupale JR, Ajayi CO, Tusiimire J, Ngwuluka NC.   +3 more
europepmc   +1 more source

Advancing Severe Plastic Deformation for Tubular Samples: Systematic Review and Machine Learning Optimization

MetalMat, EarlyView.
This review highlights recent advancements in Severe Plastic Deformation (SPD) techniques tailored for tubular samples. The mechanisms of processing are critically discussed with emphasis on microstructural control and the governing process parameters that enable refinement to ultrafine‐ and nano‐grained structures. Comparative insights into equivalent
Eman M. Zayed, Abdulrahman I. Alateyah, Waleed H. El‐Garaihy, Mahmoud Shaban, Majed Alinizzi, Nahed A. El‐Mahallawy   +5 more
wiley   +1 more source

Reconsidering Volume‐Based Drug Procurement Policy: The Consequences of Manufacturers' Optimal Production Planning and Breach Strategies

Naval Research Logistics (NRL), EarlyView.
ABSTRACT This paper examines the impacts of Volume‐Based Procurement (VBP) policies on pharmaceutical supply chains, with a focus on the strategic behaviors of manufacturers. VBP aims to reduce costs and stabilize supplies by centralizing procurement through competition based on volumes and prices.
Nani Zhou, Tong Wang, Guohua Wan
wiley   +1 more source

An Exact Method for Reliable Shortest Path Problems With Correlation

Networks, EarlyView.
ABSTRACT Shortest path problems often arise in contexts where travel times are uncertain. In these settings, reliable paths are often valued more than paths with lower expected travel times. This has led to several variants of reliable shortest path problems (RSPP) that handle travel time reliability differently. We propose an algorithmic framework for
Esteban Leiva, Santiago Morales, Daniel Yamín, Andrés L. Medaglia   +3 more
wiley   +1 more source