Results 141 to 150 of about 22,894 (307)
Indicator Regularized Non-Negative Matrix Factorization Method-Based Drug Repurposing for COVID-19. [PDF]
Front Immunol, 2020 Tang X +5 more
europepmc +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Graphical Method of Factoring the Correlation Matrix
Proceedings of the National Academy of Sciences, 1944 Not ...
openaire +3 more sources
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Factorization method for inverse elastic cavity scattering
This paper is concerned with the inverse elastic scattering problem to determine the shape and location of an elastic cavity. By establishing a one-to-one correspondence between the Herglotz wave function and its kernel, we introduce the far-field ...
Wang, Yi, Li, Shuxin, Lv, Junliang
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Factorization Method for Electromagnetic Inverse Scattering from Biperiodic Structures [PDF]
, 2012 This paper is concerned with the inverse scattering problem of electromagnetic waves from penetrable biperiodic structures in three dimensions. We study the Factorization method as a tool for reconstructing the periodic media from measured data ...
Nguyen, Dinh Liem, Lecheiter, Armin
core
Factorized Runge–Kutta–Chebyshev Methods
Journal of Physics: Conference Series, 2017 The second-order extended stability Factorized Runge-Kutta-Chebyshev (FRKC2) class of explicit schemes for the integration of large systems of PDEs with diffusive terms is presented. FRKC2 schemes are straightforward to implement through ordered sequences of forward Euler steps with complex stepsizes, and easily parallelised for large scale problems on
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Avocado: a multi-scale deep tensor factorization method learns a latent representation of the human epigenome. [PDF]
Genome Biol, 2020 Schreiber J +3 more
europepmc +1 more source