Results 71 to 80 of about 3,315,315 (285)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Suferințele tânărului Ghica [PDF]

Revista de Istorie și Teorie Literară, 2016
The subject of this presentation consists of three very little known works of the writer, economist and Liberal ideologist Ion Ghica (1816–1897), from 1835, 1838 and 1853, therefore, at least the first two ones written in his early youth.
Nicolae Mecu
doaj  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Assessment of the voltage stability of the power system using stability indices and artificial neural network

Science and Technology for Energy Transition
Voltage Stability Indicators (VSI) play a significant role in determining the voltage stability of the power system. In order to forecast the voltage instability of the system using voltage stability indicators, this paper presents an implementation of ...
Gupta Santosh Kumar, Mallik Sanjeev Kumar, Yadav Lokesh Kumar, Tripathi Jayant Mani, Ranjan Ashish, Sahu Pankaj, Rahman Md Atiqur, Kesh Rishi, Singh Vishnu   +8 more
doaj   +1 more source

Seven Immigration Myths and Facts [PDF]

, 2011
The AFL-CIO prepared Seven Immigration Myths and Facts addressing current immigration ...
AFL-CIO
core   +1 more source

The directionality of distinctively mathematical explanations [PDF]

, 2017
In “What Makes a Scientific Explanation Distinctively Mathematical?” (2013b), Lange uses several compelling examples to argue that certain explanations for natural phenomena appeal primarily to mathematical, rather than natural, facts.
Craver, Carl F., Povich, Mark
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dwie (anty)filozoficzne „gramatyki” Wittgensteina [Two (anti )philosophical grammars of Ludwig Wittgenstein] [PDF]

Analiza i Egzystencja, 2013
Wittgenstein is the author of two conceptions of “grammar”, that were meant to be tools of reaching the same goal: discrediting of the traditional, i.e. “metaphysical” questions of philosophy.
Adam Nowaczyk, Ewa Czesna
doaj  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Soft facts: Thinking practices and the architecture of reality

Daimon, 2013
It is common to criticize the idea of objectivity by claiming that we cannot make sense of any cognitive contact with the world that is not constituted by the very materials of our thinking, and to conclude that the idea must be abandoned and that the ...
Hilan Nissor Bensusan, Manuel de Pinedo García   +1 more
doaj   +1 more source