Results 91 to 100 of about 8,579,941 (287)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Archives Alive!: librarian-faculty collaboration and an alternative to the five-page paper
In the Library with the Lead Pipe, 2015 In brief: The short research paper is ubiquitous in undergraduate liberal arts education. But is this assignment type an effective way to assess student learning or writing skills?
Tom Keegan, Kelly McElroy
doaj
Frontiers in EducationAcross Wyoming’s remote educational landscapes, rural technical STEMM educators (RTSEs) engage in complex relational work supporting student navigation through challenging institutional, cultural, and physical barriers.
Rosemary McBride
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Faculty Publications 1976-77 [PDF]
, 1978 Faculty Publications 1976-77 is the fifteenth major compilation of the publications of the Faculty of Western Michigan University and is designed mainly to apprise the Faculty of the University of the breadth of writing of their ...
Western Michigan University
core +1 more source
Sustaining Educational Reforms in Introductory Physics
, 2008 While it is well known which curricular practices can improve student performance on measures of conceptual understanding, the sustaining of these practices and the role of faculty members in implementing these practices are less well understood.
C. Henderson +13 more
core +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Social SciencesAmid escalating attacks on the diversity, equity, and inclusion, Historically Black Emerging Hispanic-Serving Institutions (HBeHSIs) represent overlooked spaces of resistance in U.S. Higher education.
Dwuana Bradley +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source