Results 101 to 110 of about 8,418,501 (325)

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

open access: yesMolecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova   +26 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Facilitating Effective Food Security Policy Reform [PDF]

open access: yes
Food Security and Poverty, Downloads December 2008 - July 2009: 10,
Food Security II Faculty
core   +1 more source

Faculty Roles and Faculty-Related Topics [PDF]

open access: yesInternational Journal of Research on Service-Learning and Community Engagement, 2016
Faculty who practice service-learning and community engagement are engaged scholars who focus their teaching and research on the renewal of democracy and social and environmental issues of relevance to the broader public. Their scholarship comprises a vehicle for their personal commitments and, in some cases, their respective institution’s commitments ...
openaire   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

open access: yesMolecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh   +5 more
wiley   +1 more source

Art Studie s in Ghana: Whose Responsibility?

open access: yesLegon Journal of the Humanities, 2015
While Ghana has centuries of tradition in producing some significant art, the literature on Ghanaian art suggests a preponderance of Euro-American writing about it, and on the contrary a paucity of Ghanaian scholars’ contribution to the ...
Kwame Amoah Labi
doaj   +1 more source

The Role of HRM Practices in Predicting Faculty Turnover Intention: Empirical Evidence From Private Universities in Bangladesh [PDF]

open access: yes, 2011
The present study was designed to examine the relationship between human resource management practices and turnover intention among the faculty members of private universities in Bangladesh. The prime objective of this study was to understand whether the
Joarder, M. H. (Mohd)
core  

The Faculties of Plants [PDF]

open access: green, 1908
D. T. MacDougal
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

open access: yesMolecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik   +4 more
wiley   +1 more source

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