Results 101 to 110 of about 7,997,916 (358)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

The role of college and university faculty in the fossil fuel divestment movement

open access: yesElementa: Science of the Anthropocene, 2018
Colleges and universities have played a critical role in the growing social movement to divest institutional endowments from fossil fuels. While campus activism on fossil fuel divestment has been driven largely by students and alumni, faculty are also ...
Jennie C. Stephens   +2 more
doaj   +1 more source

Gender, Productivity, and Prestige in Computer Science Faculty Hiring Networks [PDF]

open access: yesProc. 2016 World Wide Web Conference (WWW), 1169-1179 (2016), 2016
Women are dramatically underrepresented in computer science at all levels in academia and account for just 15% of tenure-track faculty. Understanding the causes of this gender imbalance would inform both policies intended to rectify it and employment decisions by departments and individuals.
arxiv  

A neural network account to Kant's philosophical aesthetics [PDF]

open access: yesMind and Matter, 22(2), 227 - 252, 2024
According to Kant's (1724 -- 1804) philosophical aesthetics, laid down in his Critique of the Power of Judgement (1790), beauty is "subjective purposefulness", reflected by the "harmony of the cognitive faculties", which are "understanding" and "imagination". On the one hand, understanding refers to the mental capability to find regularities in sensory
arxiv   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Time, the final frontier

open access: yesMolecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain   +3 more
wiley   +1 more source

The Changing Nature of Faculty Employment [PDF]

open access: yes, 2004
[Excerpt] The last two decades of the twentieth century saw a significant growth in the shares of faculty members in American colleges and universities that are part-time or are full-time without tenure-track status.
Ehrenberg, Ronald G, Zhang, Liang
core   +2 more sources

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