Results 61 to 70 of about 74,830 (289)
Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment
Advanced Science, EarlyView.This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo +15 more
wiley +1 more source
Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy
Advanced Science, EarlyView.Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan +14 more
wiley +1 more source
Revista Hábitat Sustentable, 2018 : El objetivo de este trabajo es valorar la utilidad de la termografía infrarroja para diagnosticar en forma rápida el desempeño térmico de edificios existentes.
Carolina Ganem Karlen
doaj +1 more source
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +1 more source
Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications
Angewandte Chemie, EarlyView.Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika +9 more
wiley +2 more sources
EFFECT OF FERTILIZATION ON PRODUCTIVITY OF MAIZE [PDF]
Journal of Plant Production, 2013 Two field experiments were carried out at Abo-Swilam El-ayyat Giza Governorate, Egypt in 2010 and 2011 seasons to study the effect of combinations of four rates from each of farmyard manure (FYM) (5, 10, 15 and 20 m3/fad.), nitrogen (30, 60, 90 and 120 ...
E. Soliman +3 more
doaj +1 more source
Advanced Science, EarlyView.Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou +6 more
wiley +1 more source
Per aquí passa el canal! [PDF]
, 2013 Projecte presentat a Racons Públics - FAD 2013Sel·leccionatPostprint (published ...
Carrasco Bonet, Marta
core +1 more source
EFFECT OF SEEDING RATE AND NITROGEN FERTILIZATION LEVEL ON BREAD WHEAT UNDER RAINFED CONDITIONS OF NORTH SINAI [PDF]
Journal of Productivity and Development, 2009 This present study was carried out during 2003/2004 and 2004/2005 winter seasons in a private farm at Rafah, El-Areish, North Sinai Governorate, Egypt.
Amin Bassiouny
doaj +1 more source
Journal of Assisted Reproduction and Genetics, 2015 Morphological selection techniques of gametes and embryos are of current interest to clinical practice in ART. Although intracytoplasmic morphologically selected sperm injection (IMSI), time lapse imaging morphometry (TLIM) or quantification of chromosome numbers (PGS) are potentially useful in research, they have not been shown to be of statistically ...
Brian, Dale +2 more
openaire +2 more sources