Results 81 to 90 of about 405,381 (307)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Juan Carlos Onetti : La escritura con propósitos

Cuadernos LIRICO, 2013
We will consider the analysis of the writing processes in Juan Carlos Onetti’s novel Juntacadáveres(1964), focusing our work on documents, manuscripts and typescripts corrected by hand by the author himself. In the manuscripts where he drew up chapters 1
María Alejandra Alí
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Large-Scale Fading Characteristics and Models for Vehicle-to-Pedestrian Channel at 5-GHz

IEEE Access, 2019
Vehicle-to-Pedestrian (V2P) communication is essential to enable a reliable collision avoidance system for vehicles and vulnerable road users (VRUs). In order to develop a reliable communication system accurate channel models are required.
Ibrahim Rashdan, Fabian De Ponte Muller, Thomas Jost, Stephan Sand, Giuseppe Caire   +4 more
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

INVESTIGATION OF DOSIMETRIC PROPERTIES OF TABLE SUGAR IRRADIATED WITH GAMMA RAYS USING EPR TECHNIQUE

Gazi Üniversitesi Fen Bilimleri Dergisi
In our study, it was observed that the EPR signals of table sugar irradiated with gamma rays at 3 kGy, 5 kGy, 10 kGy increased in proportion to the increasing dose.
Gül Bayramiye Özmen, Eren Şahiner
doaj   +1 more source

Multipath and Doppler Characterization of an Electromagnetic Environment by Massive MDT Measurements From 3G and 4G Mobile Terminals

IEEE Access, 2019
This paper describes an innovative approach to radio channel characterization in UMTS and LTE mobile networks. In place of traditional drive tests (DT), which employ a single test mobile, a massive collection of georeferenced radio measurements is made ...
Andrea Scaloni, Pasquale Cirella, Mauro Sgheiz, Riccardo Diamanti, Davide Micheli   +4 more
doaj   +1 more source