Results 81 to 90 of about 520,343 (350)

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Closed-Form Coverage Probability for Downlink Poisson Network with Double Shadowed Fading [PDF]

arXiv, 2017
Performances of cellular networks over {\kappa}-{\mu} shadowed fading with long-term shadowing has been studied in the existing literature. However, the impact of {\kappa}-{\mu} shadowed fading with instantaneous shadowing on performances of cellular networks is unknown.
arxiv  

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

Molecular Oncology, EarlyView.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana, Paloma Navarro, Iván Hernández, Alejandra Ramos, Ana Montero‐Calle, Pablo Cabezas‐Sainz, Maria J Barrero, Diego Megías, Borja Vilaplana‐Martí, Carolina Epifano, Déborah Gómez‐Dominguez, Sara Monzón, Isabel Cuesta, Laura Sánchez, Rodrigo Barderas, Jesús García‐Donas, Alberto Martín, Ignacio Pérez de Castro   +17 more
wiley   +1 more source

On the Fading Number of Multiple-Input Single-Output Fading Channels with Memory [PDF]

arXiv, 2006
We derive new upper and lower bounds on the fading number of multiple-input single-output (MISO) fading channels of general (not necessarily Gaussian) regular law with spatial and temporal memory. The fading number is the second term, after the double-logarithmic term, of the high signal-to-noise ratio (SNR) expansion of channel capacity.
arxiv  

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Near-Optimal Efficient MIMO Receiver for Miniature UAV-IoT Communications

IEEE Open Journal of Vehicular Technology
This article proposes a novel Direct Detection (DD) scheme for multiple-input multiple-output (MIMO) unmanned aerial vehicle (UAV) communications where tedious, slow, and computationally demanding channel state information (CSI) estimation and detection ...
Anas Saci, Arafat Al-Dweik, Shihab Jimaa
doaj   +1 more source

Cooperative Spectrum Sensing over Generalized Fading Channels Based on Energy Detection [PDF]

arXiv, 2017
This paper analyzes the unified performance of energy detection (ED) of spectrum sensing (SS) over generalized fading channels in cognitive radio (CR) networks. The detective performance of SS schemes will be obviously affected by fading channel between communication nodes, and ED has the advantages of fast implementation, no requirement of priori ...
arxiv  

The fluctuating two-ray fading model: exact and approximate statistical characterization [PDF]

, 2017
El congreso en el que se ha presentado este artículo no genera libro de actas, por lo que el copyright no se ha transferido a IEEE.We introduce the Fluctuating Two-Ray (FTR) fading model, a new statistical channel model that consists of two fluctuating ...
Goldsmith, Andrea, Lopez-Martinez, F. Javier, Paris-Angel, Jose Francisco, Romero-Jerez, Juan Manuel   +3 more
core  

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source