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Epidemiological survey of avian adenovirus in China from 2015 to 2021 and the genetic variability of highly pathogenic Fadv-4 isolates

Infection, Genetics and Evolution, 2022
The prevalence of poultry adenovirus in China is determined using clinical diagnosis, molecular biological testing, serological testing, and LMH cell virus isolation. These methods can track and test key poultry and waterfowl breeding areas across the country. From 2015 to 2021, 9613 suspected adenovirus samples were collected from 28 provinces.
Dengyun, Niu, Jingjing, Feng, Baomin, Duan, Qiuying, Shi, Ying, Li, Zhuo, Chen, Lifang, Ma, Haixia, Liu, Yanxiao, Wang   +8 more
exaly   +3 more sources

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FAdV-4 infection induces selective mitochondrial autophagy

Veterinary Microbiology
Fowl adenovirus serotype 4 (FAdV-4) is an infectious pathogen that poses a significant threat to the poultry industry. It is widely disseminated globally and is characterized by high infection and mortality rates. Mitochondria, as multifunctional dual membrane-enclosed eukaryotic organelles, maintain cellular homeostasis through various mechanisms ...
Yujuan Niu
exaly   +3 more sources

FAdV-4-induced ferroptosis affects fat metabolism in LMH cells

Veterinary Microbiology
Ferroptosis is a form of controlled cell death that was first described relatively recently and that is dependent on the formation and accumulation of lipid free radicals through an iron-mediated mechanism. A growing body of evidence supports the close relationship between pathogenic infections and ferroptotic cell death, particularly for viral ...
Yonghe Ding, Yujuan Niu, Yuanchao Sun
exaly   +3 more sources

Novel variant infectious bursal disease virus diminishes FAdV-4 vaccination and enhances pathogenicity of FAdV-4

Veterinary Microbiology
Infectious bursal disease virus (IBDV) caused an acute and highly contagious infectious disease characterized by severe immunosuppression, causing considerable economic losses to the poultry industry globally. Although this disease was well-controlled under the widely use of commercial vaccines in the past decades, the novel variant IBDV strains ...
Zhishan, Liang, Mei, Leng, Jiamin, Lian, Yazheng, Chen, Qi, Wu, Feng, Chen, Zhanxin, Wang, Wencheng, Lin   +7 more
openaire   +2 more sources

Immunopathological effects of co-exposure to ochratoxin A and FAdV-4 in broilers

British Poultry Science
1. Immunosuppressive disorders in poultry pose a significant threat to health and productivity. Ochratoxin A (OTA), a mycotoxin and fowl adenovirus serotype 4 (FAdV-4), the causative agent of hydropericardium syndrome and inclusion body hepatitis, are each known for their immunopathological effects.
M, Imran, M K, Saleemi, A, Khan, S T, Gul, M, Jamil, M A, Alvi, A, Yar   +6 more
openaire   +2 more sources

Protein profile of FAdV-4 based on SDS-PAGE and Western blot isolated from chickens in India

Comparative Immunology, Microbiology and Infectious Diseases, 2018
Fowl adenovirus-4 (FAdV-4) causes hydropericardium syndrome (HPS) in poultry worldwide. An understanding of viral structural protein composition is important for developing novel immunodiagnostics and immunoprophylactics. Here we report isolation, culture, molecular and protein profile of FAdV-4 isolates recovered from HPS outbreaks in chicken in the ...
Prasenjit, Dhar, Aneesh, Thakur, Rajesh Kumar, Asrani, Vipin, Katoch, Mandeep, Sharma   +4 more
openaire   +2 more sources

Recombinant FAdV-4 fiber-2 protein protects chickens against hepatitis–hydropericardium syndrome (HHS)

Vaccine, 2014
Virulent fowl adenovirus (FAdV) serotype 4 strains are the etiological agents of hepatitis-hydropericardium syndrome (HHS), a highly infectious disease in chickens with severe economic impact. In the present study, three different FAdV-4 derived capsid proteins, fiber-1, fiber-2, and hexon loop-1, were expressed in a baculovirus system and tested for ...
Anna, Schachner, Ana, Marek, Barbara, Jaskulska, Ivana, Bilic, Michael, Hess   +4 more
openaire   +2 more sources

Specific-Pathogen-Free Chickens Vaccinated with a Live FAdV-4 Vaccine Are Fully Protected Against a Severe Challenge Even in the Absence of Neutralizing Antibodies

Avian Diseases, 2010
By adapting a very virulent fowl adenovirus serotype 4 (FAdV-4) to a fibroblast cell line (QT35) instead of growing the virus in chicken embryo liver cells or chicken kidney cells, it was possible to attenuate the virus. Birds infected with the attenuated virus (FAdV-4/QT35) on the first day of life expressed no adverse clinical signs and no mortality.
Esther, Schonewille, Ron, Jaspers, Guntram, Paul, Michael, Hess   +3 more
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FAdV-4-induced secondary Pasteurella multocida infection potentiates bacterial adherence and aggravates pathological damage in SPF chickens

Veterinary Microbiology
Fowl aviadenovirus (FAdV) is widely prevalent and often co-infects with other pathogens. During clinical sample testing in our laboratory, samples of FAdV and Pasteurella multocida（PM） co-infection were identified. Compared with single infections, co-infected chickens exhibited more severe clinical symptoms.
Yuxin Chen, Guizhen Yi, Yunzhen Huang, Linlin Li, Jiawen Dong, Yong Xiang, Minhua Sun, Junqin Zhang, Bin Wu   +8 more
openaire   +2 more sources

Genomic and Pathologic Characterization of the First FAdV-C Serotype 4 Isolate from Black-Necked Crane

Viruses, 2023
Suhua Li
exaly