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Development of a colloidal gold immunochromatographic strip for the rapid detection of fowl adenovirus serotype 4 using prepared penton protein-specific monoclonal antibodies. [PDF]

Front Vet Sci
Luo S, Yang B, Huang J, Wei Y, Xie Z, Li X, Wu A, Ruan Z, Wang S, Zhang Y, Li M, Xie L, Yan M, Wang W, Wei P.   +14 more
europepmc   +1 more source

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A fowl adenovirus serotype 4 (FAdV-4) Fiber2 subunit vaccine candidate provides complete protection against challenge with virulent FAdV-4 strain in chickens

Veterinary Microbiology, 2021
Hypervirulent fowl adenovirus serotype 4 (FAdV-4)-induced hepatitis-hydropericardium syndrome (HHS) with high mortality causes huge economic losses to the poultry industry worldwide. However, commercially available vaccines against FAdV-4 infection remain scarce.
Dejing Yin, Kaigong Wang
exaly   +3 more sources

FAdV-4 induce autophagy via the endoplasmic reticulum stress-related unfolded protein response

Veterinary Microbiology, 2022
Hydropericardium syndrome caused by the fowl adenovirus serotype 4 (FAdV-4) is prevalent disease in China with a high mortality rate. Many studies have demonstrated some viral infections to induce stress in the endoplasmic reticulum (ER). When the ER stress exceeds or persists, it activates autophagy, eventually triggering the onset of diseases ...
Haiying Ma, Yonghe Ding, Ke Du
exaly   +3 more sources

FAdV-4 infection induces selective mitochondrial autophagy

Veterinary Microbiology
Fowl adenovirus serotype 4 (FAdV-4) is an infectious pathogen that poses a significant threat to the poultry industry. It is widely disseminated globally and is characterized by high infection and mortality rates. Mitochondria, as multifunctional dual membrane-enclosed eukaryotic organelles, maintain cellular homeostasis through various mechanisms ...
Yujuan Niu
exaly   +3 more sources

Complete genome sequence and pathogenicity analysis of a highly pathogenic FAdV-4 strain

Research in Veterinary Science, 2023
Fowl adenovirus serotype 4 (FAdV-4) is a double-stranded DNA virus that mainly infects broiler chickens and has caused huge economic losses to the poultry industry. Recently, an FAdV-4 strain, SDLC202009, the causative pathogen of hydropericardium-hepatitis syndrome (HHS) in Liaocheng, Shandong, was isolated from commercial laying hens and propagated ...
Kaili, Wang, Cheng, Liu, Xusheng, Du, Ye, Ma, Lele, Chen, Shenliang, Cao, Jianbiao, Lu, Yubao, Li, Zhenshu, Si   +8 more
openaire   +2 more sources

Fiber1, but not fiber2, is the essential fiber gene for fowl adenovirus 4 (FAdV-4)

Journal of General Virology, 2021
Fibre is the viral protein that mediates the attachment and infection of adenovirus to the host cell. Fowl adenovirus 4 (FAdV-4) possesses two different fibre trimers on each penton capsomere, and roles of the separate fibres remain elusive. Here, we attempted to investigate the function of FAdV-4 fibres by using reverse genetics approaches. Adenoviral
Xiaohui Zou, Yejing Rong, Xiaojuan Guo, Wenzhe Hou, Bingyu Yan, Tao Hung, Zhuozhuang Lu   +6 more
openaire   +2 more sources

Novel variant infectious bursal disease virus diminishes FAdV-4 vaccination and enhances pathogenicity of FAdV-4

Veterinary Microbiology
Infectious bursal disease virus (IBDV) caused an acute and highly contagious infectious disease characterized by severe immunosuppression, causing considerable economic losses to the poultry industry globally. Although this disease was well-controlled under the widely use of commercial vaccines in the past decades, the novel variant IBDV strains ...
Zhishan, Liang, Mei, Leng, Jiamin, Lian, Yazheng, Chen, Qi, Wu, Feng, Chen, Zhanxin, Wang, Wencheng, Lin   +7 more
openaire   +2 more sources

FAdV-4-induced ferroptosis affects fat metabolism in LMH cells

Veterinary Microbiology
Ferroptosis is a form of controlled cell death that was first described relatively recently and that is dependent on the formation and accumulation of lipid free radicals through an iron-mediated mechanism. A growing body of evidence supports the close relationship between pathogenic infections and ferroptotic cell death, particularly for viral ...
Wenjing, Dong, Ke, Du, Yonghe, Ding, Yuting, Liu, Lixia, Peng, Chuanhong, Wu, Yuanchao, Sun, Zhiqiang, Li, Yujuan, Niu   +8 more
openaire   +2 more sources

Recombinant FAdV-4 fiber-2 protein protects chickens against hepatitis–hydropericardium syndrome (HHS)

Vaccine, 2014
Virulent fowl adenovirus (FAdV) serotype 4 strains are the etiological agents of hepatitis-hydropericardium syndrome (HHS), a highly infectious disease in chickens with severe economic impact. In the present study, three different FAdV-4 derived capsid proteins, fiber-1, fiber-2, and hexon loop-1, were expressed in a baculovirus system and tested for ...
Anna, Schachner, Ana, Marek, Barbara, Jaskulska, Ivana, Bilic, Michael, Hess   +4 more
openaire   +2 more sources