Results 71 to 80 of about 9,966 (258)

Fatal outcome related to drug reaction with eosinophilia and systemic symptoms: a disproportionality analysis of FAERS database and a systematic review of cases

Frontiers in Immunology
BackgroundDrug rash with eosinophilia and systemic symptoms (DRESS) is a life-threatening severe cutaneous adverse reaction.ObjectiveThis study aims to study fatal DRESS cases using FAERS database and systematic review.MethodsData of the FDA Adverse ...
Chunsu Liang, Chunsu Liang, Pengjiao An, Pengjiao An, Yizhou Zhang, Yizhou Zhang, Xin Liu, Xin Liu, Bo Zhang, Bo Zhang   +9 more
doaj   +1 more source

Incorporating spontaneous reporting system data to aid causal inference in longitudinal healthcare data [PDF]

, 2014
Inferring causality using longitudinal observational databases is challenging due to the passive way the data are collected. The majority of associations found within longitudinal observational data are often non-causal and occur due to confounding. The
Aickelin, Uwe, Reps, Jenna M.
core   +4 more sources

FDA‐Approved Biologics for CRSwNP: A Five‐Year Analysis of the FDA Adverse Event Reporting System

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 5, October 2025.
Biologics are increasingly utilized in the treatment of chronic rhinosinusitis with nasal polyps. In this study, we characterized the adverse events reported in the FDA adverse event reporting system associated with each biologic to better understand who is at greatest risk for a serious adverse event.
Radhika Duggal, Mohamad R. Chaaban
wiley   +1 more source

Drug-induced hearing disorders: a disproportionality analysis of the FAERS database

Frontiers in Pharmacology
BackgroundTo evaluate and identify reports of adverse events related to hearing impairment with drugs approved in the past 20 years, to identify new adverse reaction signals related to hearing impairment that have not yet been reported, and to improve the safety of drug treatments.MethodsThe adverse event report data from the FAERS database from the ...
Baojian Li, Xiaoling Hu, Zichen Yue
openaire   +3 more sources

Risk assessment of the top 50 drugs associated with drug-induced orthostatic hypotension: a disproportionality analysis of the FAERS and JADER databases

Scientific Reports
To use the FDA Adverse Event Reporting System (FAERS) database to identify drugs associated with orthostatic hypotension. Adverse event reports of orthostatic hypotension from Q1 2004 to Q3 2024 were obtained from the FAERS and JADER databases.
Gaocan Ren, Xiansu Chi, Pingping Huang, Jinhui Zhang, Yanqiu Ding, Lijun Guo, Qinghua Shang, Xiaochang Ma   +7 more
doaj   +1 more source

Mining directional drug interaction effects on myopathy using the FAERS database [PDF]

, 2018
Mining high-order drug-drug interaction (DDI) induced adverse drug effects from electronic health record (EHR) databases is an emerging area, and very few studies have explored the relationships between high-order drug combinations.
Chasioti, Danai, Lerner, Samuel, Li, Lang, Ning, Xia, Quinney, Sara K., Shen, Li, Yao, Xiaohui, Zhang, Pengyue   +7 more
core   +1 more source

Association of Omeprazole‐Related Myopathy With Drug–Drug and Drug–Gene Interactions Involving CYP2C19 and CYP3A4: A Nested Case–Control Study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 10, Page 654-666, October 2025.
ABSTRACT Background Omeprazole, a widely used proton pump inhibitor, has been associated with rare but serious adverse events such as myopathy. Previous research suggests that concurrent use of omeprazole with fluconazole, a potent cytochrome P450 (CYP) 2C19/3A4 inhibitor, may increase the risk of myopathy.
Eugene Jeong, Aditi Shendre, Yu Su, Xingyi Guo, Lang Li, You Chen   +5 more
wiley   +1 more source

β-Blockers and Asthma: Surprising findings from the FAERS database

Respiratory Medicine
β-Blockers are essential for cardiovascular disease management but can induce respiratory issues, particularly with non-selective β-blockers. Their safety in asthmatic patients is debated.This study investigates the link between different classes of β-blockers and the risk of asthma and asthma-like adverse events (AEs) using data from the Food and Drug
Mario Cazzola, Josuel Ora, Luigino Calzetta, Paola Rogliani, Maria Gabriella Matera   +4 more
openaire   +5 more sources

Retrospective analysis of adverse events with spironolactone in females reported to the United States Food and Drug Administration

International Journal of Women's Dermatology, 2020
Background: Spironolactone is an off-label acne treatment that is commonly prescribed due to its low cost, efficacy, and tolerability. Objective: This study aimed to classify the most common adverse reactions associated with spironolactone in women of ...
Yu Wang, BA, Shari R. Lipner, MD, PhD
doaj   +1 more source

Phase separation dynamics in colloid-polymer mixtures: the effect of interaction range

, 2012
Colloid-polymer mixtures may undergo either fluid-fluid phase separation or gelation. This depends on the depth of the quench (polymer concentration) and polymer-colloid size ratio.
Bartlett, Paul, Faers, Malcolm A., Royall, C. Patrick, Zhang, Isla   +3 more
core   +1 more source