Results 81 to 90 of about 5,845,611 (294)
Advancing Dynamic Fault Tree Analysis
, 2016 This paper presents a new state space generation approach for dynamic fault trees (DFTs) together with a technique to synthesise failures rates in DFTs. Our state space generation technique aggressively exploits the DFT structure --- detecting symmetries,
Junges, Sebastian +2 more
core +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
An In Situ Automated System for Real-Time Monitoring of Failures in Large-Scale Field Emitter Arrays
InstrumentsNano-scale vacuum transistors (NVCTs) based on field emission have the potential to operate at high frequencies and withstand harsh environments, such as radiation, high temperatures, and high power.
Reza Farsad Asadi +5 more
doaj +1 more source
Independent Orbiter Assessment (IOA): Analysis of the crew equipment subsystem [PDF]
The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL) are presented. The IOA approach features a top-down analysis of the hardware to determine failure modes, criticality ...
Graham, L. +3 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Nanomaterials, 2019 Rapid progress in the performance of organic devices has increased the demand for advances in the technology of thin-film permeation barriers and understanding the failure mechanisms of these material systems.
Vipin Chawla +9 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
IEEE AccessPower distribution systems consist of critical infrastructure with various categories of assets that require rigorous maintenance programs to ensure their reliability and performance for all stakeholders.
Attanayake Mudiyanselage Sakura Rancy Harshani Attanayake +2 more
doaj +1 more source
Approaches to Methods of Risk Analysis and Assessment Regarding the Gas Supply to a City
Energies, 2018 Analysis and assessment of the reliability and safety of a gas-supply system is a key issue, given its status as critical infrastructure. A gas-supply system is characterised by continuous operation and a consequent need to achieve a high level of ...
Barbara Tchórzewska-Cieślak +1 more
doaj +1 more source