Results 81 to 90 of about 15,405,604 (296)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Structural Performance of Outdoor Mechanical Garages under Combustion Conditions

Fire
In this paper, the firing process and structural failure behavior of outdoor mechanical car parks are innovatively investigated under diverse conditions, leveraging fire experiments, FDS fire simulation, and finite element simulation.
Yin Zhang, Zuocai Wang, Yang Li, Hongsheng Ma, Zhan Guo   +4 more
doaj   +1 more source

Experimental and numerical analysis on bending and tensile failure behavior of calcium phosphate cements.

Journal of The Mechanical Behavior of Biomedical Materials, 2020
Since their discovery in the 1980s, injectable self-setting calcium phosphate cements (CPCs) are frequently used in orthopedic, oral and maxillofacial surgery due to their chemical resemblance to the mineral phase of native bone.
A. Paknahad, Nathan W. Kucko, S. Leeuwenburgh, L. Sluys   +3 more
semanticscholar   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Sample-specific behavior in failure models of disordered medial

, 1996
The concept ''sample-specific'' is suggested to describe the behavior of disordered media close to macroscopic failure. it is pointed out that the transition from universal scaling to sample-specific behavior may be a common phenomenon in failure models ...
Zhao KH, Xu JB, 白以龙, 夏蒙棼, Song ZQ, Xia, MF (reprint author), BEIJING UNIV,DEPT PHYS,BEIJING 100871,PEOPLES R CHINA.   +5 more
core  

Failure Behavior of Corrugated Pressure Cylindrical Shells with Variable Wall Thickness under Uniform External Pressure

Journal of Marine Science and Engineering
The main load-bearing structure of submarines is the pressure shell. Shell failures are usually caused by high hydrostatic pressure and its own potential geometric imperfections. This paper proposes a cylindrical shell with a strong corrugated stiffening
Jianliang Sun, Xu Zhang, Yuanhe Zhang, Xianghui Lu, Yan Peng   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Can the failure speak? Militant failure in the academy [PDF]

, 2019
Academia is rife with structural issues. We are witnessing a mental health crisis among staff and students, hiring and employment practices are institutionally sexist and racist, and staff are increasingly expected to be a triple threat (research ...
Clare, Nick
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source