Results 121 to 130 of about 8,243,947 (299)

Dynamic Responses and Failure Characteristics of Deep Double U-Shaped Caverns under Disturbing Loads

Applied Sciences
The instability of double-cavern structure subjected to dynamic disturbances is a key issue for deep rock engineering. To investigate the dynamic responses of deep double U-shaped caverns, comprehensive analyses are conducted by Particle Flow Code (PFC2D)
Lisha Liang, Xibing Li, Zhixiang Liu
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Triaxial compressive mechanical properties and failure characteristics of limestone-concrete composites after acid corrosion

Shuiwen dizhi gongcheng dizhi
Limestone-concrete composites are widely found in engineering structures in southwest China, yet they are highly susceptible to degradation under acid-rain exposure, posing significant safety risks.
Jie WANG, Shisong YUAN, Bin DU
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Mechanical characteristics and load transfer mechanism of grout-rock dual media in penetrative fracture grouting

Meitan kexue jishu
Grouting is a primary technique for enhancing the stability of fractured rock masses, and the load-transfer mechanism at the grout-rock interface significantly influences the failure of grouted rock masses.
Zhenhua LI, Mengsen LIU, Feng DU, Wenqiang WANG, Minglei ZHAI, Jianhang SHI   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Study on Damage Behavior and Anti-Explosion Performance of Steel Fiber-Reinforced Cellular Concrete Under Underwater Contact Explosion

Buildings
To explore the damage mitigation mechanism of steel fiber-reinforced cellular concrete (SFR-CC) under underwater explosion loading, this study systematically analyzes two key variables: steel fiber volume fraction (0.5%, 1.0%, 1.5%, and 2.0%) and ...
Hu Huang, Shubo Dai, Kelei Cao, Changxing Tang, Xiancai Zhang, Changhui Zhang, Qingming Qiu   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Perfectionism, fear of failure, and affective responses to success and failure: The central role of fear of experiencing shame and embarrassment [PDF]

, 2009
This study investigated how different aspects of perfectionism in athletes (N = 388) related to the different fears of failure proposed by Conroy et al.
Stoeber, Joachim, Stoeber, J, Sagar, SS, Sagar, S.S.   +3 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source