Results 101 to 110 of about 8,243,947 (299)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Study on the Flexural Performance of Composite Wall Panels with Ceramsite Foam Concrete and Normal Concrete

Buildings
Traditional exterior walls are heavy, offer insufficient insulation, and have poor durability, making it challenging to meet the combined requirements of energy efficiency and structural enclosure performance.
Chongming Gao, Zhenbao Li, Hua Ma, Muhan Li, Nannan Shi, Suen Tian   +5 more
doaj   +1 more source

Asymptotic behavior of mixture failure rates [PDF]

Mixtures of increasing failure rate distributions (IFR) can decrease at least in some intervals of time. Usually this property is observed asymptotically as time tends to infinity , which is due to the fact that a mixture failure rate is ‘bent down’, as ...
Maxim S. Finkelstein, Veronica Esaulova
core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Feeding and failure to thrive in early infancy [PDF]

, 2003
The aims of this thesis were fourfold. The first aim was the early identification of cases of non organic failure to thrive in a community based study and of randomly selected controls.
Colquhoun, Fiona
core  

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Uniaxial Compressive Failure Characteristics and Fractal Analysis of Mud–Sand Composite Rock Samples Based on Acoustic Emission Tests

Fractal and Fractional
In order to study the influence of rock combination types on their mechanical properties and failure characteristics, uniaxial compression tests of single rock samples and combined rock samples were conducted.
Changzheng Zhao, Shenggen Cao, Shihui Lang, Shuyu Du, Chiyuan Che   +4 more
doaj   +1 more source

Contemporary Characteristics and Outcomes in Chagasic Heart Failure Compared With Other Nonischemic and Ischemic Cardiomyopathy

, 2017
BACKGROUND: Chagas' disease is an important cause of cardiomyopathy in Latin America. We aimed to compare clinical characteristics and outcomes in patients with heart failure (HF) with reduced ejection fraction caused by Chagas' disease, with other ...
Echeverria, L. E., Zile, M. R., Jhund, P. S., McMurray, J. J. V., Gomez, E. A., Abraham, W. T., Kober, L., Rouleau, J. L., Dickstein, K., Swedberg, Karl,, Ramires, F., Shen, L., Solomon, S. D., Martinez, F., Gimpelewicz, C. R., Bodanese, L. C., Packer, M.   +16 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Study on Creep Behavior and Constitutive Model of Carbonaceous Mudstone Under Hydro-mechanical Coupling

工程科学与技术
ObjectiveCarbonaceous mudstone exhibits low mechanical strength, water-induced disintegration, and reduced structural compactness. It is widely distributed in the mountainous strata of Southwestern China, where tunneling activities frequently traverse ...
YU Mingyuan, LIU Yaoru, HUANG Shuai, LIU Baoguo, WU Chao   +4 more
doaj