Results 91 to 100 of about 3,630,714 (312)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effects of Stress Concentration on the Mechanical Properties of Carbon Fiber Reinforced Plastic

International Journal on Smart Material and Mechatronics, 2017
Mechanical properties of conventional CFRP plates with small holes were investigated systematically. Those artificial holes are considered to be rivet connection between CFRP and other materials. The machining holes were employed with different number (n=
Ryo Naito, Mitsuhiro Okayasu, Daisuke Fukuyama   +2 more
doaj  

Study on mining-induced failure mechanism of the floor aquifuge based on microseismic monitoring

河南理工大学学报. 自然科学版
ObjectivesTo investigate the mining-induced failure characteristics of the floor aquifuge and ensure safe working face extraction， a study on the failure patterns of the floor aquifuge based on microseismic monitoring was conducted.MethodsWith the 16001 ...
Zhang Yanli, Yang Ming, Qi Lingling, Hao Dian, Wang Chunxia   +4 more
doaj   +1 more source

Job Characteristics in Nursing and Cognitive Failure at Work

Safety and Health at Work, 2011
Stressors in nursing put high demands on cognitive control and, therefore, may increase the risk of cognitive failures that put patients at risk. Task-related stressors were expected to be positively associated with cognitive failure at work and job control was expected to be negatively associated with cognitive failure at work.Ninety-six registered ...
Elfering A, Grebner S, Dudan A
openaire   +4 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Energy characteristics of saturated Jurassic sandstone in western China under different stress paths

Deep Underground Science and Engineering
To study the energy evolution and failure characteristics of saturated sandstone under unloading conditions, rock unloading tests under different stress paths were conducted.
Yi Yang, Jian Lin, Yun Wu, Shilong Peng, Wanhang Shao, Lining Yang   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Measuring the energy handling capability of metal oxide varistors [PDF]

, 2001
Metal oxide varistors are widely used in many power electronics circuits to protect against transient over voltages. Certain applications are very demanding on the energy handling capability of the varistors.
Ahmed, M. M. R., Penlington, Roger, Putrus, G.A., Ran, L.   +3 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source