Results 91 to 100 of about 8,243,947 (299)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Effects of Stress Concentration on the Mechanical Properties of Carbon Fiber Reinforced Plastic

International Journal on Smart Material and Mechatronics, 2017
Mechanical properties of conventional CFRP plates with small holes were investigated systematically. Those artificial holes are considered to be rivet connection between CFRP and other materials. The machining holes were employed with different number (n=
Ryo Naito, Mitsuhiro Okayasu, Daisuke Fukuyama   +2 more
doaj  

Study on mining-induced failure mechanism of the floor aquifuge based on microseismic monitoring

河南理工大学学报. 自然科学版
ObjectivesTo investigate the mining-induced failure characteristics of the floor aquifuge and ensure safe working face extraction， a study on the failure patterns of the floor aquifuge based on microseismic monitoring was conducted.MethodsWith the 16001 ...
Zhang Yanli, Yang Ming, Qi Lingling, Hao Dian, Wang Chunxia   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Energy characteristics of saturated Jurassic sandstone in western China under different stress paths

Deep Underground Science and Engineering
To study the energy evolution and failure characteristics of saturated sandstone under unloading conditions, rock unloading tests under different stress paths were conducted.
Yi Yang, Jian Lin, Yun Wu, Shilong Peng, Wanhang Shao, Lining Yang   +5 more
doaj   +1 more source

Mechanical Behavior of Sandstone Under Partial Water Immersion: Implications for Building Foundations and Underground Structures

CivilEng
Localized water infiltration in rock masses can significantly compromise the stability of foundations and underground structures. Conventional assessments often rely on average water content, while overlooking the spatial heterogeneity of water ...
Yiming Li, Bin Gan, Peizhao Chen, Shibin Tang, Chun Zhu, Shun Ding   +5 more
doaj   +1 more source

Research on Failure Characteristics and Failure Models for Superalloy GH4169

应用数学和力学, 2021
TAN Xueming, WANG Ruifeng, GUO Xiaojun, MENG Weihua, GUO Weiguo   +4 more
openaire   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source