Results 111 to 120 of about 3,630,714 (312)

Study on dynamic response characteristics of jointed coal mass under impact load

Meikuang Anquan
Based on the similarity theorem, the material ratio of similar coal body is determined, and the single-layer thin-plate coal body is prepared by pouring.
Jianfeng LIU
doaj   +1 more source

Nonparametric control charts for bivariate high-quality processes [PDF]

, 2012
For attribute data with (very) low rates of defectives, attractive control charts can be based on the maximum of subsequent groups of r failure times, for some suitable r≥1, like r=5.
Albers, Willem
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Research on Failure Characteristics and Failure Models for Superalloy GH4169

应用数学和力学, 2021
TAN Xueming, WANG Ruifeng, GUO Xiaojun, MENG Weihua, GUO Weiguo   +4 more
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Study on Shear Failure Characteristics of Oil Shale under High-temperature Steam Treatment

Taiyuan Ligong Daxue xuebao
Purposes In the process of in-situ steam-assisted oil shale extraction, the shear strength of oil shale plays a crucial role in the stability of injection and production wells as well as the mining gallery.
Jingzhe CAO, Dong YANG, Zhiqin KANG, Lihong FENG   +3 more
doaj   +1 more source

Predicting Criminal Recidivism Using "Split Population" Survival Time Models [PDF]

In this paper we develop a survival time model in which the probability of eventual failure is less than one, and in which both the probability of eventual failure and the timing of failure depend (separately) on individual characteristics. We apply this
Ann Dryden Witte, Peter Schmidt
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Theory and numerical simulation study on the plastic slip failure mechanism of multi-layered coal seam Floors-A case analysis

Frontiers in Earth Science
Coal seam mining induces disturbances in underground floors, leading to plastic failure, which presents significant safety risks, particularly in areas with underlying pressurized water.
Zheng Kong, Xuyang Chen, Xufeng Wang, Dongsheng Zhang, Dongsheng Zhang, Liang Chen, Shiru Guo   +6 more
doaj   +1 more source