Results 111 to 120 of about 8,243,947 (299)

Effect of Indenter Angle on Bearing Performance of Coal and Accompanying Rocks Under Point Load and Characterization of Mechanical Parameters

Energy Science & Engineering
Coal, mudstone, sandstone, and limestone, which are common in coal mines, were selected as research objects, and 60°, 90°, and 120° indenters were used to conduct point load tests to study the deformation and failure laws of rocks under point loads. This
Qian Wang, Yujiang Zhang, Delong Cui, Guorui Feng, Yunlou Du, Shuai Zhang, Haojie Cheng, Zhengjun Zhang   +7 more
doaj   +1 more source

Study on dynamic response characteristics of jointed coal mass under impact load

Meikuang Anquan
Based on the similarity theorem, the material ratio of similar coal body is determined, and the single-layer thin-plate coal body is prepared by pouring.
Jianfeng LIU
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Study on Shear Failure Characteristics of Oil Shale under High-temperature Steam Treatment

Taiyuan Ligong Daxue xuebao
Purposes In the process of in-situ steam-assisted oil shale extraction, the shear strength of oil shale plays a crucial role in the stability of injection and production wells as well as the mining gallery.
Jingzhe CAO, Dong YANG, Zhiqin KANG, Lihong FENG   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Theory and numerical simulation study on the plastic slip failure mechanism of multi-layered coal seam Floors-A case analysis

Frontiers in Earth Science
Coal seam mining induces disturbances in underground floors, leading to plastic failure, which presents significant safety risks, particularly in areas with underlying pressurized water.
Zheng Kong, Xuyang Chen, Xufeng Wang, Dongsheng Zhang, Dongsheng Zhang, Liang Chen, Shiru Guo   +6 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source