Results 71 to 80 of about 8,243,947 (299)

The clinical characteristics of women with recurrent implantation failure

Journal of Obstetrics and Gynaecology, 2013
Recurrent implantation failure (RIF) refers to failure to conceive after three or more in vitro fertilisation (IVF) or embryo transfer cycles. Implantation failure may be due to embryo or uterine factors. There are many controversies surrounding the investigation and management of this condition.
C, Coughlan, X, Yuan, T, Nafee, J, Yan, N, Mariee, T C, Li   +5 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Ivabradine in Heart Failure

, 2017
Background: The sinus node inhibitor ivabradine was approved for patients with heart failure (HF) after the ivabradine and outcomes in chronic HF (SHIFT [Systolic Heart Failure Treatment With the IF Inhibitor Ivabradine Trial ...
Das, D., Ulf Dahlström, Justin A. Ezekowitz, Howlett, Jonathan,, Dahlstrom, U, Das, D, Lund, LH, Savarese, G,, Debraj Das, Fu, M, Lund, Lars H.,, Savarese, G., Gianluigi Savarese, Howlett, J, Michael Fu, Ezekowitz, Justin A.,, Ezekowitz, J. A., Lars H. Lund, Fu, Michael,, Jonathan Howlett, Das, Debraj,, Lund, L. H., Howlett, J., Dahlstrom, U., Dahlström, Ulf,, Savarese, Gianluigi,, Ezekowitz, JA   +26 more
core   +1 more source

Can the failure speak? Militant failure in the academy [PDF]

, 2019
Academia is rife with structural issues. We are witnessing a mental health crisis among staff and students, hiring and employment practices are institutionally sexist and racist, and staff are increasingly expected to be a triple threat (research ...
Clare, Nick
core   +1 more source

Baseline characteristics of 547 new onset heart failure patients in the PREFERS heart failure study

, 2022
AIM: We present the baseline characteristics of the PREFERS Stockholm epidemiological study on the natural history and course of new onset heart failure (HF) aiming to improve phenotyping focusing on HF with preserved left ventricular ejection fraction ...
Eriksson, Maria J.,, Wallen, Hakan,, Ulrika Löfström, Eva Maret, Cabrera, Carin, for the Stockholm County/Karolinska Institutet 4D heart failure investigators, Håkan Wallén, Jenny Stenudd, Persson, Hans,, Stenudd, Jenny, Cecilia Linde, Linde, Cecilia, Patrik Lyngå, Linde, Cecilia,, Lyngå, Patrik, Weden, Ulla,, Persson, Bengt,, Ekstrom, Mattias,, Lund, Lars H.,, Wallén, Håkan, Maria J. Eriksson, Cabrera, Carin,, Lynga, Patrik,, Maret, Eva, Hans Persson, Ekström, Mattias, Maret, Eva,, Lofstrom, Ulrika,, Persson, Bengt, Persson, Hans, Bengt Persson, Lars H. Lund, Lund, Lars H., Stenudd, Jenny,, Mattias Ekström, Hage, Camilla, Wedén, Ulla, Ulla Wedén, Camilla Hage, Eriksson, Maria J., Hage, Camilla,, Löfström, Ulrika, Carin Cabrera   +42 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Effect of water pressure and axial static stress on evolution of impact energy and damage characteristics of red sandstone

Meitan xuebao
Deep underground project takes place in an environment characterised by high water pressure and geostress. This poses a significant risk of disasters such as water surges and destabilisation of the peripheral rock body, especially under dynamic ...
Jiefang JIN, Yu WANG, Lixing FANG, Huiying XIONG, Youfeng XIAO, Xiaowang PENG   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source