Results 61 to 70 of about 8,243,947 (299)

Study on the Mechanical Properties and Failure Mechanisms of Coal–Rock Composite Specimens Considering Variations in Weaker Components

Applied Sciences
To clarify the influence of α (rock–coal height ratio) and λ (rock–coal strength ratio) on the mechanical properties and failure characteristics of coal–rock composite specimens, where the weaker component varies with rock properties, four sets of coal ...
Ronghuan Cai, Yishan Pan, Feiyu Liu
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Study on Acoustic Emission Response and Failure Characteristics of Rock–Proppant–Rock Composite Constructions Under Uniaxial Compression

Applied Sciences
To reveal the bearing and instability mechanisms after filling proppants in the blasting pressure-relief fracture, four types of proppant-containing sandstone composite construction with interface inclinations of 0°, 4°, 8°, and 12° were prepared.
Nao Lv, Xiao Xu, Bing Cheng, Haibo Wang
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Pre-failure deformation characteristics of geomaterials

, 1999
Most of the papers submitted to session la on "Laboratory tests" deal with clayey and sandy soils while only a limited number of studies are devoted to the stiffness characteristics of gravels and rocks.
Rampello, S, VIGGIANI, GIULIA, Viggiani, GMB   +2 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Influence of Periodic Temperature on Salt Rock Acoustic Emission, Strength, and Deformation Characteristics

Applied Sciences
During the long-term operation of salt cavern gas storage, multiple injections and extractions of gas will cause periodic temperature changes in the storage, resulting in thermal fatigue damage to the surrounding rock of the salt cavern and seriously ...
Yuxi Guo, Yan Qin, Nengxiong Xu, Huayang Lei, Junhui Xu, Bin Zhang, Shuangxi Feng, Liuping Chen   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Experimental study on seismic performance of a novel splice joint in hybrid concrete-steel structures

Frontiers in Materials
The revitalization of aging urban districts can be significantly advanced through the redevelopment of existing buildings using hybrid concrete-steel structures with added stories.
Xiaotong Ma, Xiaotong Ma, Jinyu Wang, Tianxiang Guo, Chao Bao, Fusheng Cao   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source