Results 81 to 90 of about 8,243,947 (299)

Failure Characteristics and Evolution Law of Overburden Structure Under Repeated Mining of Close‐Distance Coal Seam Group in Ningdong Mining Area

Energy Science & Engineering
It is difficult to control the mine pressure in the coal face under the close coal seam group. On the basis of the mining background of 4‐1#, 4‐2#, and 4‐3# coal seams in the I01 mining area of the Ningdong mining area, the fracture characteristics and ...
Shilin Song, Xuesheng Liu, Yunliang Tan, Xuebin Li, Shenglong Yang, Yu Zhang   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Test Device for Evaluating Cement Sheath Seal Integrity under Cyclic Loading

Shiyou jixie, 2021
To study the failure mode and mechanism of the cement sheath in the annulus of oil and gas wellbore under pressure or temperature changes, a test device for evaluating the integrity of the cement sheath under cyclic loading is established. The device can
Guan Zhigang, Liao Hualin, Lin Zhiwei, Xie Shiyuan, Zhao Xiaofeng   +4 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Power-law characteristics of damage and failure of ceramic coating systems under three-point bending

, 2016
Damage and failure of ceramic coatings bonded on alloy substrates was studied by observing crack evolution in the coating systems under in situ three-point bending tests with corresponding load-displacement curves. A damage and catastrophic failure model
Liang, LH, Liu HY, Liang LH(梁立红), Li XN, Wang YB, Wei YG(魏悦广)   +5 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Pre-splitting weakening failure characteristics of hard overburden and height control mechanism of water-conducting fracture zone

Meitan kexue jishu
In order to address the issue of high development of hard overlying rock water-conducting fracture zones in deep coal mining and achieve water-preserved coal mining by reducing the height of water-conducting fracture zones, a new method is proposed in ...
Yujun ZHANG, Youwei LI, Jie XIAO, Zhiwei ZHANG, Jiawei LI   +4 more
doaj   +1 more source

Natriuretic Peptides in Chronic Heart Failure [PDF]

, 2019
Normal brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) levels are helpful in excluding chronic heart failure in the ambulatory setting, although they have been studied less well and possibly less accurately than in acute care.
Sandra Sanders-van Wijk, Brunner-La Rocca, Hanspeter, Hans-Peter Brunner-La Rocca, Brunner-La Rocca, Hanspeter; id_orcid, Sanders - van Wijk, Sandra   +4 more
core   +1 more source