Results 91 to 100 of about 793,861 (307)
Measurement Science ReviewMeasuring and evaluating the condition of pneumatic systems (PS) is an important identification tool for many industrial applications. Therefore, this paper focuses on the detection of changes (faults) in these circuits by analysing system pressures. The
Vagas Marek, Majercak Ondrej
doaj +1 more source
Failure detection using support vector machine and artificial neural networks: A comparative study [PDF]
, 2011 Failure detection is a crucial step for condition based maintenance. The importance of failure detection necessitates an efficient and effective failure pattern identification method.
Kumar, Uday, Fuqing, Yuan, Galar, Diego
core
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Early Failure Detection and Diagnostics of High Speed Self Aligning Journal Bearing [PDF]
Because of their high load carrying capacity and low cost, journal bearings are widely used to support the rotor of industrial machinery with high loads, such as steam turbines, centrifugal compressors and pumps.
Gu, Fengshou +3 more
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N-Tox® - Early warning of nitrification toxicity for activated sludge treatment [PDF]
, 2006 N-Tox® is a new technique for evaluating the nitrification efficiency in industrial or municipal activated sludge systems, using direct measurement of nitrous oxide (N20) as an indicator of nitrification failure.
Stephenson, Tom +3 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Immunological failure of first-line and switch to second-line antiretroviral therapy among HIV-infected persons in Tanzania: analysis of routinely collected national data. [PDF]
, 2015 OBJECTIVES: Rates of first-line treatment failure and switches to second-line therapy are key indicators for national HIV programmes. We assessed immunological treatment failure defined by WHO criteria in the Tanzanian national HIV programme. METHODS: We
Ramadhani, Angela +6 more
core +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source