Results 111 to 120 of about 793,861 (307)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Leak detection using instantaneous frequency analysis [PDF]
, 2012 Leaking pipes are a primary concern for water utilities around the globe as they compose a major portion of losses. Contemporary interest surrounding leaks is well documented and there is a proliferation of leak detection techniques. Although the reasons
M. F., Ghazali, ghazali, mohd fairusham
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
A LDDoS-Aware Energy-Efficient Multipathing Scheme for Mobile Cloud Computing Systems
IEEE Access, 2017 The multi-homed mobile devices in the mobile cloud computing (MCC) systems can improve their throughput by allocating the application data over several paths simultaneously, enabled by the promising Multipath TCP (MPTCP) technology.
Yuanlong Cao +5 more
doaj +1 more source
Model-Based Fault Detection & Control Design Applied to a Pneumatic Application [PDF]
, 2010 In safety critical applications it is important to detect faults that may compromise system safety and to take appropriate action. This paper discusses research carried-out on the development and validation of a model-based fault detection and isolation (
Goodall, R. +15 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Improvements of a Failure Database for Marine Diesel Engines Using the RCM and Simulations
Energies, 2019 Diesel engines are widely used in marine transportation as a direct connection to the propeller and as electrical principal or auxiliary generator sets. The engine is the most critical piece of equipment on a vessel platform; therefore, the engine’ ...
Francisco Vera-García +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source