Results 131 to 140 of about 793,861 (307)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Cooperative Failure Detection in Multi-Overlay Environments [PDF]
, 2012 [[abstract]]Multi-overlay environments have emerged due to the rapidly widespread of P2P applications. However, the synergy of multiple co-existing overlays still has not been fully exploited yet.
Hsu, Chin-Jung;Chung, Wu-Chun;Lai, Kuan-Chou;Li, Kuan-Ching;Chung, Yeh-Ching
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
A two filters strategy for failure detection [PDF]
, 1987 International audienceThis paper is concerned with the problem of a failure detection for one dimensional system evolving in a steady state. The detected failures are characterized by n order linear models.
Ragot, José +3 more
core +2 more sources
Flexible failure detection with k-FD [PDF]
, 2004 Many people rightly consider that failure detection should be provided as a generic distributed system service to be used to support fault-tolerance within many applications, in spite of possibly very diverse requirements.
Katayama, Takuya +2 more
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Failure Mode Classification for Rolling Element Bearings Using Time-Domain Transformer-Based Encoder
SensorsIn this paper, we propose a Transformer-based encoder architecture integrated with an unsupervised denoising method to learn meaningful and sparse representations of vibration signals without the need for data transformation or pre-trained data. Existing
Minh Tri Vu +3 more
doaj +1 more source
Redundancy relations and robust failure detection [PDF]
, 1984 All failure detection methods are based on the use of redundancy, that is on (possible dynamic) relations among the measured variables. Consequently the robustness of the failure detection process depends to a great degree on the reliability of the ...
Lou, X. C. +3 more
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source