Results 91 to 100 of about 931,469 (314)
Applied SciencesReportedly, structural failures in membrane structures have occurred frequently, mostly originating from localized damage caused by intense loads on the membrane surface.
Wenrui Li +3 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Deformation mechanism of gob‐side entry at top coal caving mining face: A numerical study
Energy Science & EngineeringTo investigate the significant deformation of the surrounding rock within the dynamic pressure zone of the gateroad, this study utilized the tailgate of the 1506 longwall face in Anyang Coal Mine as the engineering context.
Jie Zhang +6 more
doaj +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Reliability Analysis of Power IGBT Modules
机车电传动, 2013 Firstly, the module concept, packaging procedures, reliability and failure rules was presented. Then, the standard tests methodologies for investigating module reliability including endurance and environment tests were discussed. Lastly, the main failure
WANG Yan-gang, Jones Steve, LIU Guo-you
doaj
MetalsIn the context of an increasing interest in the use of high-performance steels in the construction industry due to their superior mechanical properties, understanding the behaviour and assessing the performance of dissimilar welded connections becomes ...
Anna Ene, Aurel Stratan, Ioan Both
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Experimental study on the load bearing behavior of shored mechanically stabilized earth wall
Frontiers in Earth ScienceShored mechanically stabilized earth (SMSE) walls have been increasingly applied in the projects of widening existing roads or new construction of roads on slopes because of their good carbon emission reduction and mechanical performance.
Dongdong Pang +6 more
doaj +1 more source
Research on Bearing Mechanism of Strut-and-Tie Model for Punching Failure of Independent Foundation Under Column [PDF]
, 2021 Jie Deng
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source