Results 71 to 80 of about 965,338 (266)
Experimental research on tensile strength of gravelly soil under different gravel contents
Yantu gongcheng xuebao, 2019 The tensile strength of gravelly soil is one of the important indexes for resisting the cracking of earth core rockfill dams. Based on the self-developed uniaxial tensile test mould, a series of uniaxial tensile tests are carried out on the gravel soil ...
JI En-yue 1,2,3, CHEN Sheng-shui 1,2, ZHU Jun-gao 3, FU Zhong-zhi 1,2
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Mechanisms underlying heart failure [PDF]
Drug Discovery Today: Disease Mechanisms, 2010 Heart failure is a syndrome with high mortality and morbidity where cardiac function is inadequate to meet metabolic needs of the body. Heart failure is now one of the greatest public health problems for the developed world. Approximately 500,000 new patients are diagnosed with heart failure in the United States each year.
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Mechanisms of acute renal failure
British Journal of Anaesthesia, 1996 Acute renal failure can be defined as an abrupt decline in renal function with a decrease in glomerular filtration rate (GFR) resulting in the retention of nitrogenous waste products. Acute renal failure has conventionally been classified as (a) prerenal failure, denoting a disorder in the systemic circulation that causes renal hypoperfusion.
C J, Lote, L, Harper, C O, Savage
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Mechanical Unloading in Heart Failure
Journal of the American College of Cardiology, 2018 Myocardial injury induces significant changes in ventricular structure and function at both the cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure. Unloading left ventricular pressure has been studied in both the short-term and long-term settings, as a means of preventing or reversing cardiac remodeling.
Nir, Uriel +4 more
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
layered rock, shield tunnel, model test, segment lining, anchor bolt, compressible ceramic
Yantu gongcheng xuebao, 2018 A new dilatancy equation is proposed by adding a factor to the dilatancy equation of Cambridge model, and this factor can adjust the shape of curve between the dilatancy ratio and the stress ratio for coarse-grained soils, and can reflect the nonlinear ...
GUO Wan-li 1, ZHU Jun-gao 1,2, PENG Wen-ming 3
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
On Two Approaches to Slope Stability Reliability Assessments Using the Random Finite Element Method
Applied Sciences, 2019 The random finite element method has been increasingly used in the geotechnical community to investigate the influence of soil spatial variability and to bridge the gap between a traditional design and a reliability-based design. There are two approaches
Yajun Li +3 more
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