Results 71 to 80 of about 12,735,996 (314)
Experimental research on tensile strength of gravelly soil under different gravel contents
Yantu gongcheng xuebao, 2019 The tensile strength of gravelly soil is one of the important indexes for resisting the cracking of earth core rockfill dams. Based on the self-developed uniaxial tensile test mould, a series of uniaxial tensile tests are carried out on the gravel soil ...
JI En-yue 1,2,3, CHEN Sheng-shui 1,2, ZHU Jun-gao 3, FU Zhong-zhi 1,2
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
layered rock, shield tunnel, model test, segment lining, anchor bolt, compressible ceramic
Yantu gongcheng xuebao, 2018 A new dilatancy equation is proposed by adding a factor to the dilatancy equation of Cambridge model, and this factor can adjust the shape of curve between the dilatancy ratio and the stress ratio for coarse-grained soils, and can reflect the nonlinear ...
GUO Wan-li 1, ZHU Jun-gao 1,2, PENG Wen-ming 3
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Journal of the mechanics and physics of solids, 2019 Sandwich core materials that offer superior mechanical properties at minimum weight are essential in designing high-performance sandwich structures. Hierarchical materials are ideal templates for this purpose. In this paper, we investigate the mechanical
Qianqian Wu +8 more
semanticscholar +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
On Two Approaches to Slope Stability Reliability Assessments Using the Random Finite Element Method
Applied Sciences, 2019 The random finite element method has been increasingly used in the geotechnical community to investigate the influence of soil spatial variability and to bridge the gap between a traditional design and a reliability-based design. There are two approaches
Yajun Li +3 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Yantu gongcheng xuebao, 2018 Based on the preliminarily designed construction plan of a soil-rockfill dam for Longwangding tailing dam project in Shaxi Copper Mine, the soil-rockfill materials with three different stone contents (5%, 15% and 30%) are compounded.
WANG Liang-feng 1, WANG Bin 1, CHEN Sheng-shui 2, LI Yue 3
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