Results 71 to 80 of about 5,450,980 (351)

Influences of vertical drainage wells on stability of expansive soil canals in North Xinjiang

Yantu gongcheng xuebao, 2020
The water conveyance canal in North Xinjiang is a periodic water supply canal, and the "wetting-drying" circulation caused by canal water leakage may significantly reduce the strength of expansive soils and further affect the stability of the expansive ...
DENG Ming-jiang 1, CAI Zheng-yin 2, 3, GUO Wan-li 3, HUANG Ying-hao 2, 3, ZHANG Chen 3
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Heart 'omics' in AGEing (HOMAGE): design, research objectives and characteristics of the common database. [PDF]

, 2014
Heart failure is common in older people and its prevalence is increasing. The Heart 'omics' in AGEing (HOMAGE) project aims to provide a biomarker approach that will improve the early diagnosis of heart failure.
Rocca, Hans-Peter Brunner-La, Heymans, Stephane, Staessen, JA, Pocock, Stuart, Zannad, Faiez, Bauters, C, Brunner-La Rocca, Hans-Peter; id_orcid, Thijs, Lutgarde, Heymans, S, Cleland, J.G., Pocock, S, Staessen, Jan A., Mebazaa, A, Delles, C, Thijs, L, Masson, Serge, Bauters, Christophe, Kuznetsova, Tatiana, Tomaschitz, A, McDonald, K, Pinet, Florence, Collier, T, Mamas, Mamas, Pinet, F, Jacobs, Lotte, Mebazaa, Alexandre, Sever, P, Jin, Yu, Cleland, JG, Kuznetsova, T, Latini, Roberto, Rouet, P, Mamas, M, Cleland, John G F, Sever, Peter, Jin, Y, Latini, R, Delles, Christian, Rouet, Philippe, Brunner-La Rocca, Hans-Peter, Zannad, F, Brunner-La Rocca, HP, Jacobs, L, Pieske, Burket, Diez, Javier, Diez, J, Cleland, John GF, Masson, S, McDonald, Kenneth, Pieske, B, Staessen, Jan A, Cleland, John G.F., Rocca, HP, Collier, Timothy, Tomaschitz, Andreas, Pieske, Burkert   +55 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Can the failure speak? Militant failure in the academy [PDF]

, 2019
Academia is rife with structural issues. We are witnessing a mental health crisis among staff and students, hiring and employment practices are institutionally sexist and racist, and staff are increasingly expected to be a triple threat (research ...
Clare, Nick
core   +1 more source

Effects of porosity on strength and deformation of rockfill materials

Yantu gongcheng xuebao, 2018
In view of the rockfill materials utilized in a 300 m - grade high earth-rock core rockfill dam to be constructed, large static triaxial tests under different porosities are performed to analyze the influences of porosity on strength and deformation of ...
XU Wei-wei1 , SHI Bei-xiao 2,3, CHEN Sheng-shui 2, LING Hua 2,3
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Design of a crab-like bistable mechanism for nearly equal switching forces in forward and backward directions

, 2018
A compliant bistable mechanism with a crab-like structure for nearly equal switching forces in the forward and backward directions is developed. It consists of four crab-leg-like beams and a shuttle mass.
Dung-An Wang, 王東安, Ngoc Dang Khoa Tran   +2 more
core   +1 more source