Results 51 to 60 of about 12,735,996 (314)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Multiaxial fatigue behavior of aluminum alloy thin-walled notched specimens based on DIC
Cailiao gongcheng, 2021 Focusing on the influence of notch on the multiaxial fatigue performance of material, the proportional multiaxial fatigue test was carried out on 7075-T651 aluminum alloy thin-walled notched specimens with variable equivalent stress amplitude.
CHEN Ya-jun +3 more
doaj +1 more source
Failure mechanism of silica coated polypropylene fibres for Fibre Reinforced Concrete (FRC)
, 2020 This work investigates the effect of a fast, acid-catalysed sol-gel silica nano-coating on the mechanical performance of draw-wire Polypropylene (PP) fibres used as dispersed reinforcement in Fibre Reinforced Concrete (FRC).
C. Signorini +4 more
semanticscholar +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Failure mechanisms in denture adhesives [PDF]
Dental Materials, 2016 The mechanical properties of bio adhesives in oral care application are expected to be critical in defining the stability and release of devices such as dentures from the oral tissue. A multiscale experimental mechanical approach is used to evaluate the performance of denture adhesive materials.The inherent mechanical behavior of denture fixatives was ...
An, Yiran +4 more
openaire +4 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Effects of porosity on strength and deformation of rockfill materials
Yantu gongcheng xuebao, 2018 In view of the rockfill materials utilized in a 300 m - grade high earth-rock core rockfill dam to be constructed, large static triaxial tests under different porosities are performed to analyze the influences of porosity on strength and deformation of ...
XU Wei-wei1 , SHI Bei-xiao 2,3, CHEN Sheng-shui 2, LING Hua 2,3
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Yantu gongcheng xuebao, 2017 According to the landslide characteristics of the slope of the reservoir bank of Longjiang Hydropower Station in Yunnan Province, laboratory tests are conducted to investigate the characteristics of the landslide under the combined effects of rainfall ...
LI Zhuo 1, 2, 3, HE Yong-jun 1, 2, SHENG Jin-bao 1, 2, 3, LI Hong-en 1, 2, LI Zheng 1, 2, YANG Yang 1, 2
doaj +1 more source
Strength of connections in precast concrete structures [PDF]
Facta Universitatis. Series: Architecture and Civil Engineering, 2011 The available experimental and numerical results of many studies of behavior of reinforced concrete connections for different stages of loading, up to fracture loading, are presented and analyzed in this paper.
Folić Radomir +2 more
doaj +1 more source