Results 61 to 70 of about 12,735,996 (314)
Discusion on Failure Mechanism of Piping
Chemical Engineering Transactions, 2016 Supposing that the layer is consisted of two ideal elastic spheres with different diameters, the permeability coefficient of the layer can be calculated. After piping taking place and small grains being carried away, the permeability coefficient will change.
Fan Z.C., Sun J.
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Immune Mechanisms in Heart Failure [PDF]
European Journal of Heart Failure, 2017 Abstract Elevated levels of circulating pro-inflammatory biomarkers in patients with both ischaemic and non-ischaemic heart failure (HF) correlate with disease severity and prognosis. Experimental studies have shown activation of immune response mechanisms in the heart to provoke cardiac adverse remodelling and cause left ventricular ...
Yingying, Zhang +2 more
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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Yantu gongcheng xuebao, 2018 The extended finite element method combined in ABAQUS software is used to simulate the propagation of crest cracks of an earth core rockfill dam. For the simplified plane FEM model with initial cracks, the conclusions are obtained as follows: the main ...
JI En-yue 1,2, CHEN Sheng-shui 1,2, FU Zhong-zhi 1,2, ZHU Jun-gao 3
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
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Centrifugal model tests on section form of drainage channel of barrier dams
Yantu gongcheng xuebao, 2017 The centrifugal model tests on barrier dams overtopping are carried out based on the grain composition of Tangjiashan landslide dam, and the influence laws on the discharge process, released water and the size of the residual dam section of the drainage ...
ZHAO Tian-long 1,2, CHEN Sheng-shui 2,3, FU Chang-jing 1,2, ZHONG Qi-ming 2,3, HOU Ying-wei 1
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Mechanisms underlying heart failure [PDF]
Drug Discovery Today: Disease Mechanisms, 2010 Heart failure is a syndrome with high mortality and morbidity where cardiac function is inadequate to meet metabolic needs of the body. Heart failure is now one of the greatest public health problems for the developed world. Approximately 500,000 new patients are diagnosed with heart failure in the United States each year.
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Mechanisms of heart failure in obesity [PDF]
Obesity Research & Clinical Practice, 2014 Heart failure is a leading cause of morbidity and mortality and its prevalence continues to rise. Because obesity has been linked with heart failure, the increasing prevalence of obesity may presage further rise in heart failure in the future. Obesity-related factors are estimated to cause 11% of heart failure cases in men and 14% in women. Obesity may
Imo A. Ebong +4 more
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
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