Results 81 to 90 of about 12,735,996 (314)

Mechanisms of acute renal failure

British Journal of Anaesthesia, 1996
Acute renal failure can be defined as an abrupt decline in renal function with a decrease in glomerular filtration rate (GFR) resulting in the retention of nitrogenous waste products. Acute renal failure has conventionally been classified as (a) prerenal failure, denoting a disorder in the systemic circulation that causes renal hypoperfusion.
C J, Lote, L, Harper, C O, Savage
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Mechanical Unloading in Heart Failure

Journal of the American College of Cardiology, 2018
Myocardial injury induces significant changes in ventricular structure and function at both the cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure. Unloading left ventricular pressure has been studied in both the short-term and long-term settings, as a means of preventing or reversing cardiac remodeling.
Nir, Uriel, Gabriel, Sayer, Shiva, Annamalai, Navin K, Kapur, Daniel, Burkhoff   +4 more
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Method for parameter extraction of geometric features of gravel materials based on artificial intelligence analysis of CT images

Yantu gongcheng xuebao
Sand and gravel mixture are widely used fill material for earth and rock dams, with its mechanical properties significantly influenced by particle geometric characteristics such as gradation, shape, and spatial arrangement.
PENG Jiayi1, 2 , FU Zhongzhi1, 2, SHEN Zhenzhong3, XU Siyuan1, 2
doaj   +1 more source

Method for estimating at-rest lateral pressure coefficient of coarse-grained soils

Yantu gongcheng xuebao, 2018
The at-rest earth pressure coefficient K0 is a basic mechanical parameter of soils. So studying K0 of coarse-grained soils is of important theoretical value and practical significance in geotechnical engineering. At present, there are few apparatuses and
JIANG Ming-jie 1,2, LU Xiao-ping 3, ZHU Jun-gao 1,2, JI En-yue 4,5, GUO Wan-li 4,5
doaj   +1 more source

3D printed meta-sandwich structures: Failure mechanism, energy absorption and multi-hit capability

Materials & Design (1980-2015), 2018
A new class of lightweight and 3D printable architected sandwich structures, named as meta-sandwich structures, has been introduced. These lightweight sandwich structures, which have been made of mechanical metamaterials as the core, show many advantages
H. Sarvestani, A. Akbarzadeh, A. Mirbolghasemi, K. Hermenean   +3 more
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source