Results 81 to 90 of about 2,619,969 (311)
Discusion on Failure Mechanism of Piping
Chemical Engineering Transactions, 2016 Supposing that the layer is consisted of two ideal elastic spheres with different diameters, the permeability coefficient of the layer can be calculated. After piping taking place and small grains being carried away, the permeability coefficient will change.
Fan Z.C., Sun J.
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Mechanisms of heart failure in obesity [PDF]
Obesity Research & Clinical Practice, 2014 Heart failure is a leading cause of morbidity and mortality and its prevalence continues to rise. Because obesity has been linked with heart failure, the increasing prevalence of obesity may presage further rise in heart failure in the future. Obesity-related factors are estimated to cause 11% of heart failure cases in men and 14% in women. Obesity may
Imo A. Ebong +4 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Yantu gongcheng xuebao, 2018 The extended finite element method combined in ABAQUS software is used to simulate the propagation of crest cracks of an earth core rockfill dam. For the simplified plane FEM model with initial cracks, the conclusions are obtained as follows: the main ...
JI En-yue 1,2, CHEN Sheng-shui 1,2, FU Zhong-zhi 1,2, ZHU Jun-gao 3
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Mechanisms underlying heart failure [PDF]
Drug Discovery Today: Disease Mechanisms, 2010 Heart failure is a syndrome with high mortality and morbidity where cardiac function is inadequate to meet metabolic needs of the body. Heart failure is now one of the greatest public health problems for the developed world. Approximately 500,000 new patients are diagnosed with heart failure in the United States each year.
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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Centrifugal model tests on section form of drainage channel of barrier dams
Yantu gongcheng xuebao, 2017 The centrifugal model tests on barrier dams overtopping are carried out based on the grain composition of Tangjiashan landslide dam, and the influence laws on the discharge process, released water and the size of the residual dam section of the drainage ...
ZHAO Tian-long 1,2, CHEN Sheng-shui 2,3, FU Chang-jing 1,2, ZHONG Qi-ming 2,3, HOU Ying-wei 1
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Experimental research on tensile strength of gravelly soil under different gravel contents
Yantu gongcheng xuebao, 2019 The tensile strength of gravelly soil is one of the important indexes for resisting the cracking of earth core rockfill dams. Based on the self-developed uniaxial tensile test mould, a series of uniaxial tensile tests are carried out on the gravel soil ...
JI En-yue 1,2,3, CHEN Sheng-shui 1,2, ZHU Jun-gao 3, FU Zhong-zhi 1,2
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