Results 91 to 100 of about 5,959,491 (252)

Right Ventricular Myocardial Biomarkers in Human Heart Failure

, 2017
Background: Right ventricular (RV) dysfunction contributes to mortality in chronic heart failure (HF). However, the molecular mechanisms of RV failure remain poorly understood, and RV myocardial bio-markers have yet to be developed. Methods and Results:
楊鎧鍵, di Salvo, Thomas G.;Yang, Kai-Chien;Brittain, Evan;Absi, Tarek;Maltais, Simon;Hemnes, Anna   +1 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Mechanisms of failure of jointed rock masses and the behaviour of steep slopes [PDF]

, 1998
The geomorphological behaviour of steep jointed rock slopes has been studied using distinct element method computer models. In order to model steep slopes effectively, methodologies need to be combined from the studies of environmental modellers ...
Kimber, Owen Graham
core  

Impact response and failure mechanisms of ultrahigh modulus polyethylene fiber composites and polyethylene fiber-carbon fiber hybrid composites

, 1998
The impact response and failure mechanisms of ultrahigh modulus polyethylene (UHMPE) fiber composites and UHMPE fiber-carbon fiber hybrid composites have been investigated.
冼杏娟, Xian, XJ (reprint author), Chinese Acad Sci, Inst Mech, 15 Zhong Guan Cun Rd, Beijing 100080, Peoples R China.   +1 more
core   +2 more sources

Evaluation of the performance of reinforced concrete beams with 3D-printed permanent formwork

Journal of Intelligent Construction
Understanding the advantages of combining traditional construction methods and 3D concrete printing is the gateway to the general structural applicability of three-dimensional concrete printing (3DCP) technology. To further this objective, in this study,
Jingyuan Guan, Li Wang, Yimiao Huang, Guowei Ma, Yaxin Tao   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Failure Mechanisms in Bolted CFRP

, 1998
An experimental investigation on the damage mechanisms of mechanically fastened joints in composite laminates is presented. This information concerning damage mechanisms is required before developing damage progression models.
F. L. Matthews, P. P. Camanho, S. Bowron
core   +1 more source