Results 101 to 110 of about 5,959,491 (252)

Failure Mode and Mechanisms of Gneiss Open-Pit Slopes in Cold Regions—A Case Study of the 14 September 2023 Landslide at the Jinbao Mine in Xinjiang, China

Applied Sciences
Extensive high and steep open-pit slopes in gneiss are distributed in cold regions at high altitudes or high latitudes of China, such as Qinghai, Tibet, and Xinjiang, posing significant hazards to mine safety.
Lihui Han, Yangjie Guo, Hechuan Yan, Jiaming Yuan, Ming Zhang   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Mechanisms of failure and outcome of secondary surgical interventions after thoracic endovascular aortic repair (TEVAR)

, 2011
We evaluated mechanisms of failure and outcome of secondary surgical interventions after thoracic endovascular aortic repair (TEVAR)
Czerny, Martin, Thierry Carrel, Grimm, Michael, Jürg Schmidli, Michel, Marc, Julia Dumfarth, Schmidli, Jürg, Marc Michel, Michael Grimm, Gottfried Sodeck, Dumfarth, Julia, Carrel, Thierry, Martin Czerny, Marek Ehrlich, Sodeck, Gottfried, Ehrlich, Marek   +15 more
core   +1 more source

Temperature dependence of ESD effects on 28 nm FD‐SOI MOSFETs

Engineering Reports
The failure mechanisms caused by electrostatic discharge (ESD) effects at ambient temperatures ranging from −75 to 125°C are investigated by Silvaco TCAD simulator.
Yiping Xiao, Chaoming Liu, Yanqing Zhang, Chunhua Qi, Guoliang Ma, Tianqi Wang, Mingxue Huo   +6 more
doaj   +1 more source

Review of Health Monitoring and Intelligent Fault Diagnosis for High-Strength Bolts: Failure Mechanisms, Multi-Modal Sensing, and Data-Driven Approaches

Buildings
High-strength bolted connections are fundamental load-bearing components in critical engineering infrastructures such as wind turbines, bridges, and heavy machinery.
Yingjie Wang, Guanghui Chu, Zhifang Sun, Fei Yang, Jun Yang, Xiaoli Sun, Yi Zhao, Shuai Teng   +7 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Structural evolution and failure mechanisms of APS tantalate high-entropy ceramic coatings in response to thermal cycle up to 1500 °C

Journal of Advanced Ceramics
Thermal barrier coatings (TBCs) with high working temperatures and long service life are indispensable for the hot-end components of gas turbines and aircraft engines.
Jiankun Wang, Lin Chen, Luyang Zhang, Hao Xu, Qinglin Zhou, Jing Feng   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Thermal performance and cycling failure of bismuth phosphosilicate glass frits for alumina/Kovar alloys sealing

Materials Research Express
With bismuth zinc phosphate glass used for sealing Alumina (Al _2 O _3 ) and Kovar Alloy (Fe–Co–Ni, 4J33), the effects of glass composition on its thermal properties, wetting behavior, interfacial microstructure, sealing reliability and failure ...
Yinzhong Zhang, Juanjuan Xing, Hua Tong
doaj   +1 more source